نتایج جستجو برای: atovaquone
تعداد نتایج: 456 فیلتر نتایج به سال:
Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance to novel unrelated antimalarials. To test this hypothesis, different Plasmodium falciparum clones having varying numbers of preexisting resistance mechanisms were treated with two new antimalarial age...
The bc 1 complex of the mitochondrial respiratory chain is essential for Plasmodium falciparum proliferation, the causative agent of human malaria. Therefore, this enzyme is an attractive target for antimalarials. However, biochemical investigations of the parasite enzyme needed for the study of new drugs are challenging. In order to facilitate the study of new compounds targeting the enzyme, w...
Long-term malaria prophylaxis is hampered by a lack of standardization and compliance. Advice should be individually optimized to achieve a high degree of protection and compliance. Individual risk assessment takes into consideration the duration of stay in the endemic area, the individual exposure, the seasonal transmission rates, and the drug-resistance situation.Methods for prevention of exp...
Several drug development strategies, including optimization of new antimalarial drug combinations, have been used to counter malaria drug resistance. We evaluated the malaria Sybr green I-based fluorescence (MSF) assay for its use in in vitro drug combination sensitivity assays. Drug combinations of previously published synergistic (atovaquone and proguanil), indifferent (chloroquine and azithr...
Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro evolution of decoquinate-resistant parasites and subsequent comparative genomic analysis to the drug-sensitive parental strain revealed resistance was conferred by two nonsynonymous single nucleotide polymorphisms in the gene encoding cytoc...
Introduction: Malaria is a highly contagious disease. According to W.H.O., its cases are expected to increase due to climate changes. Despite eradication efforts, malaria still remains one of the most significant causes of morbidity and mortality in tropical and subtropical regions. Many different antimalarial regimens are used; however resistance is emerging to many of them. Purpose: This crit...
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