نتایج جستجو برای: atorvastatin calcium
تعداد نتایج: 172112 فیلتر نتایج به سال:
Background: In the current scenario, emergence of antimicrobial resistance has made it difficult to treat bacterial infections alone using antibacterial agents. Methods: Milk samples collected from 100 mastitis affected cows August 2018 June 2019 and were stored at 4°C. After species confirmation, isolates subjected ABST screened for genes - mecA, blaTEM PCR. Minimum Inhibitory Concentration (M...
Objective: The objective of the study was to evaluate the dose dependent effects of atorvastatin on rat kidneys. Methods: The selected doses of atorvastatin were administered orally for 17 days to rats. The statin induced nephrotoxicity was accessed by carrying out renal function tests and is by renal histopathology analysis. Measurements of antioxidant enzymes were also carried out to check wh...
chronic idiopathic urticaria is defined as recurrent hives occurring for at least 6 weeks. in the majority of cases, there is no identifiable underlying etiology despite extensive evaluation. a subset of these patients is classified as having autoimmune urticaria defined by the presence of a functional igg antibody to the α subunit of the high-affinity ige receptor (fceria) or to ige. the...
In the present study, we tested our hypothesis that atorvastatin exerts its anti-inflammation effect via suppressing LPS-induced rapid upregulation of Toll-like receptor 4 (TLR4) mRNA and its downstream p38, ERK, and NF-κB signaling pathways in human umbilical-vein endothelial cells (HUVECs) and human aortic endothelial cells (HAECs). TLR4 mRNA expression and its downstream kinase activities in...
BACKGROUND This work focuses on the development of atorvastatin utilizing zein, a natural, safe, and biocompatible polymer, as a nanosized formulation in order to overcome the poor oral bioavailability (12%) of the drug. METHODS Twelve experimental runs of atorvastatin-zein nanosphere formula were formulated by a liquid-liquid phase separation method according to custom fractional factorial d...
Atorvastatin is widely used to lower blood cholesterol and to reduce risk of cardiovascular disease-associated complications. Epidemiological investigations and preclinical studies suggest that statins such as atorvastatin have antitumor activity for various types of cancer. Tuberous sclerosis (TSC) is a tumor syndrome caused by TSC1 or TSC2 mutations that lead to aberrant activation of mTOR an...
BACKGROUND Atorvastatin showed a number of cardiovascular benefits, however, the role and underlying molecular mechanisms of short-term atorvastatin-mediated protection remain unclear. METHODS 30 rats were randomly divided into 3 groups: sham group, acute myocardial infarction model group and atorvastatin group. The rats of acute myocardial infarction model were established by ligation of the...
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