The aim was to test the hypothesis that atopy increases the occurrence of chronic bronchitis. Relations between atopy, smoking, and chronic bronchitis were studied in farmers. The data were from two successive postal surveys and a skin prick tested subsample. The cross-sectional study consisted of 9017 farmers. Those 6899 farmers who did not have chronic bronchitis at the beginning and who cont...

Previous studies have shown that hydrolysed rice protein formula (HRPF) is well tolerated in infants with cow’s milk allergy (CMA). Children receiving HRPF showed similar growth and development of clinical tolerance to those receiving an extensively hydrolysed cow’s milk protein (eHF) formula. We present 3 cases of infants in which CMA symptoms persisted with HRPF feeding, and resolved with an ...

BACKGROUND Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease. AIM To analyse the influence of gene-gene interactions in the development of atopy. METHODS A total of 2055 ethnically identical participants aged 10-18 years living in rura...

OBJECTIVE IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human asthma and allergy. METHODS Functional SNPs of FCGR2A (FcγRIIA-131His>Arg, rs1801274), FC...

Atopy is generally considered to be caused by interaction of genetic and environmental factors. Recently, an association of a C to T transition in the promoter region of the CD14 gene on chromosome 5q31.1 and atopic phenotypes was reported in a population study of school children in the United States. The aim of the present study was to investigate the association of the C allele of the CD14/-1...

We have previously demonstrated that the adult outcome of childhood asthma differs from that of wheeze occurring only in the presence of infection. This paper examines the role of atopy in relation to outcome. We investigated the atopic status, current symptoms and bronchial reactivity to methacholine of 235 subjects aged 34-40 yrs, originally classified at age 10-15 yrs as having asthma (asthm...

BACKGROUND The association between atopy and asthma is attenuated in non-affluent populations, an effect that may be explained by childhood infections such as geohelminths. OBJECTIVE To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association. METHODS We performed nested case...

despite preliminary evidence, the role of probiotic and synbiotic in treatment of the atopic dermatitis has shown varying results. we aimed to evaluate whether synbiotic supplementation decrease severity of atopic dermatitis (ad) in childhood. in a randomized double blind-placebo controlled trial, we evaluated the synbiotic supplementation efficiency on the treatment of atopic dermatitis. infan...

The pathomechanism of atopic eczema is complex. Two of the most important exogenous factors for atopic eczema are allergenic and irritant substances. In this study we investigate the combined effect of topical aeroallergens and irritation on the skin of atopic individuals. We performed patch testing with several aeroallergens (atopy patch test) and with an irritant, sodium lauryl sulphate, on c...