نتایج جستجو برای: atomoxetine

تعداد نتایج: 721  

Journal: :World Journal Of Advanced Research and Reviews 2022

The present work described the development of a rapid resolution liquid chromatographic (RRLC) method for atomoxetine in its pharmaceutical dosage form Strattera ®. analysis was achieved on Agilent Eclipse XDB C18 column (50 mm x 4.6 i.d, 1.8 particle size) using mixture aqueous 0.04 M Glacial acetic acid and 0.03M triethylamine (TEA), pH - Acetonitril (42 : 58, v/v) as mobile phase at flow rat...

Journal: :Journal of child and adolescent psychopharmacology 2004
Thomas E Brown

Atomoxetine and stimulants have both been demonstrated effective as single agents for treatment of attention deficit hyperactivity disorder in children, adolescents, and adults. However, attention deficit hyperactivity disorder symptoms in some patients do not respond adequately to single-agent treatment with these medications, each of which is presumed to impact dopaminergic and noradrenergic ...

Journal: :Child and Adolescent Psychiatry and Mental Health 2009
Ralf W Dittmann Peter M Wehmeier Alexander Schacht Anette Minarzyk Martin Lehmann Kathrin Sevecke Gerd Lehmkuhl

BACKGROUND The degree of ADHD-related difficulties - reflecting overall impairment, social functioning, and quality of life - may be perceived differently by adolescent patients, parents and physicians. The primary aim of this study was to investigate ADHD-related difficulties during atomoxetine treatment, as perceived by the three different raters. Secondary objectives focused on effectiveness...

Journal: :Pediatrics 2004
Theodore A Henderson Keith Hartman

2013
Patrick T Udvardi Karl J Föhr Carolin Henes Stefan Liebau Jens Dreyhaupt Tobias M Boeckers Andrea G Ludolph

Attention-deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder. The norepinephrine transporter (NET) inhibitor atomoxetine, the first nonstimulant drug licensed for ADHD treatment, also acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist. The compound's effects on gene expression and protein levels of NET and NMDAR subunits (1, 2A, and 2B) a...

2014
Lenard A. Adler David B. Clemow David W. Williams Todd M. Durell

OBJECTIVE To evaluate the effect of atomoxetine treatment on executive functions in young adults with attention-deficit/hyperactivity disorder (ADHD). METHODS In this Phase 4, multi-center, double-blind, placebo-controlled trial, young adults (18-30 years) with ADHD were randomized to receive atomoxetine (20-50 mg BID, N = 220) or placebo (N = 225) for 12 weeks. The Behavior Rating Inventory ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Barbara J Ring Jennifer S Gillespie James A Eckstein Steven A Wrighton

Studies were performed to determine the human enzymes responsible for the biotransformation of atomoxetine to its major metabolite, 4-hydroxyatomoxetine, and to a minor metabolite, N-desmethylatomoxetine. Utilizing human liver microsomes containing a full complement of cytochrome P450 (P450) enzymes, average K(m) and CL(int) values of 2.3 microM and 103 microl/min/mg, respectively, were obtaine...

2008
John Lechleiter

The Division of Drug Marketing, Advertising, and Communications (DDMAC) of the U.S. Food and Drug Administration (FDA) has reviewed a professional sales aid (AT39696) for Strattera (atomoxetine HCl) (Strattera) submitted by Eli Lilly and Company (Eli Lilly) under cover of Form FDA 2253. This piece is false or misleading because it broadens the indication for and overstates the efficacy of Strat...

2016
Andrea Ward Cheryl Carrico Elizabeth Powell Philip M. Westgate Laurie Nichols Anne Fleischer Lumy Sawaki

BACKGROUND Intensive, task-oriented motor training has been associated with neuroplastic reorganization and improved upper extremity movement function after stroke. However, to optimize such training for people with moderate-to-severe movement impairment, pharmacological modulation of neuroplasticity may be needed as an adjuvant intervention. OBJECTIVE Evaluate safety, as well as improvement ...

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