نتایج جستجو برای: atll
تعداد نتایج: 284 فیلتر نتایج به سال:
Marneros and colleagues have described multiple skin erosions in a patient receiving pralatrexate, a novel inhibitor of dihydrofolate reductase, for the treatment of adult T-cell lymphoma/leukemia (ATLL).1 These skin erosions were not due to the toxicity of the drug on keratinocytes but rather to the apoptosis of intra-epidermal atypical T cells as evidenced by the selective erosions on pre-exi...
BACKGROUND Human T-cell leukemia virus-associated adult T-cell leukemia-lymphoma (ATLL) has a very poor prognosis, despite trials of a variety of different treatment regimens. Virus expression has been reported to be limited or absent when ATLL is diagnosed, and this has suggested that secondary genetic or epigenetic changes are important in disease pathogenesis. METHODS AND FINDINGS We prosp...
Human T cell leukemia virus (HTL V) is the name by which we have designated a family of related retroviruses from humans. HTLV type I (HTLV-I) is the name we gave the first human retrovirus isolate. HTLV-I is endemic at low rates in different parts of the world, including southern Japan, the Caribbean, South and Central America, the southeastern United States, and especially in Africa. Seroepid...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 47-year-old woman visited our hospital because of sudden-onset headache. She had no history of and specific physical findings including skin lesions, organomegaly, or lymphadenopathy. Her blood cell counts were as follows:tate dehydrogenase level was as hi...
The persistence of human T-cell leukemia/lymphoma virus-I (HTLV-I)-infected cells is dependent upon clonal expansion and up-regulation of telomerase (hTERT). We have previously found that in interleukin (IL)-2-independent transformed HTLV-I cells, Tax strongly activates the hTERT promoter through nuclear factor-kappaB (NF-kappaB)-mediated Sp1 and c-Myc activation. In IL-2-dependent cells and ad...
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