Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...

OBJECTIVE To determine if Chinese individuals with non syndromic cleft lip with or without cleft palate (CL/P) display more dermatoglyphic asymmetry than unaffected relatives or controls. DESIGN Case-control study with two control groups (genetically related and unrelated). SETTING AND SAMPLE POPULATION A total of 500 CL/P probands from Shanghai, China, 421 unaffected relatives, and 66 cont...

The large number of mild traumatic brain injuries (mTBIs) occurring each year, along with increasing evidence that these injuries are more serious than previously thought, has created a demand to understand how mTBIs occur so that they can be prevented. The use of helmet-based instrumentation to estimate head impact biomechanics in sports is an increasingly popular method by which to study mTBI...

PURPOSE To investigate lacrimal gland (LG) immunophysiological and immune-mediated inflammatory process (IMIP) phenotype diversity. METHODS Ex vivo matured dendritic cells (mDC) were loaded with acinar cell microparticles (MP). Peripheral blood lymphocytes (PBL) were activated in mixed cell reactions with mDC and injected directly into autologous, unilateral LG (1°ATD-LG) of two rabbit cohort...

A total of 34 dynamic matched frontal sled tests were performed, 17 low (2.5g, Δv=4.8kph) and 17 medium (5.0g, Δv=9.7kph), with five male human volunteers of approximately 50th percentile height and weight, a Hybrid III 50th percentile male ATD, and three male PMHS. Each volunteer was exposed to two impulses at each severity, one relaxed and one braced prior to the impulse. A total of four test...

Head trauma is the most frequent injury sustained by children in car crashes, and the neck plays a key role in governing head kinematics during the crash. Pediatric anthropomorphic test devices (ATDs) are used to assess the risk of head injury, yet the pediatric ATD neck is a size-scaled model of the adult ATD neck, with no consideration for the tissue properties and morphological changes durin...

Alternating Treatments Designs (ATD) with random assignment of the treatments to the measurement times provide very powerful single-case experiments. However, complete randomization might cause too many consecutive administrations of the same treatment to occur in the design. In order to exclude these possibilities, an ATD with restricted randomization can be used. In this article we provide a ...

OBJECTIVE Recent studies have raised the question as to whether a dysregulation of the neurotransmitter serotonin may contribute to the alterations in mood seen in anorexia nervosa (AN). People with AN tend to be anxious, obsessional, perfectionistic, and harm avoidant. These traits are premorbid and persist after recovery. It has been suggested that increased activity of brain serotonin system...

Serotonergic involvement has been implicated in preferential consumption of treat foods. We tested the effect of acute tryptophan depletion (ATD) on food consumption by overweight and lean adults with and without a history of recurrent major depressive disorder (MDD). ATD and taste-matched placebo challenges were administered double-blind in counter-balanced order. Participants were classified ...

OBJECTIVE To compare cost of treating hyperthyroidism with antithyroid medications (ATD) versus radioactive iodine (RAI). As secondary outcome we also analyzed data in terms of remission rates. METHODS This was a retrospective comparative analysis of hyperthyroid patients treated with ATD or RAI from January 2000 to December 2005. Cost of ATD, TSH. FT4, doctors visits; thyroid technetium scan...