The nucleophilic addition reactions of allyl isothiocyanate (AITC) with alanine, glycine, and five alanine and/or glycine containing di- and tripeptides were investigated in model aqueous solutions of pH 6, 8, and 10 at 25 degrees C for 2-4 weeks. The formation of primary adducts, i.e., N-allylthiocarbamoyl amino acids (ATC-amino acids) or ATC-peptides, their transformation products, i.e., 3-al...

Targeting B7-H3 over-expressed tumor cells with anti-B7-H3 monoclonal antibodies inhibits tumor growth. Here we demonstrated the expression of B7 family homologue 3 (B7-H3) in a wide range of human tumor cells and further investigated whether B7-H3 could be served as a target for T-cell mediated immunotherapy against human cancers. The specific cytotoxic activity of activated T cell (ATC) armed...

Experimental and numerical techniques are employed to assess the thermomechanical behavior of ceramic and organic flip chip packages under power cycling (PC) and accelerated thermal cycling (ATC). In PC, nonuniform temperature distribution and different coefficients of thermal expansion of each component make the package deform differently compared to the case of ATC. Traditionally, reliability...

Since 1981, the Automatic Train Control (ATC) devices have been used to maintain a safe distance between trains on the Yamanote and Keihin-Tohoku lines in Tokyo. Although shorter train headways have been desired for years to increase the line capacities, this has been impossible with the conventional ATC. The authors have developed a new ATC system, the Digital ATC system, to replace the conven...

BACKGROUND The transcription factor NF-ATc plays a key role in the activation of many early immune response genes and is regulated by subcellular localization. NF-ATc translocates from the cytoplasm to the nucleus in response to a rise in intracellular calcium, and immediately returns to the cytoplasm when intracellular calcium levels fall. The rapid nuclear exit of NF-ATc is thought to be one ...

Novel therapeutic approaches are required for the treatment of anaplastic thyroid carcinoma (ATC), an incurable disease resistant to current available therapies. Aurora B is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers including ATC and represents a potential target for chemotherapy. The effects of AZD1152, a specific Aurora...

This paper proposes a solution to air traffic control (ATC) using an enhanced SIMD machine model called an Associative Processor (AP). This differs from previous ATC systems that are designed for MIMD computers and have a great deal of difficulty meeting the predictability requirements for ATC, which are critical for meeting the strict certification standards required for safety critical softwa...

Cationic dry strength agents (DSAs) are commonly used for paper strengthening. However, before they are applied, another chemical called an anionic trash catcher (ATC) is often used to pretreat pulp to neutralize the negative dissolved and colloidal substances (DCS), increasing the effectiveness of the subsequently added cationic DSA. However, in many cases, the negativity of the fibers is also...

The analytical target cascading (ATC) optimization technique for hierarchical systems demonstrates convergence properties only under assumptions of convexity and continuity. Many practical engineering design problems, however, involve a combination of continuous and discrete variables resulting in the development of mixed integer nonlinear programming (MINLP) formulations. While ATC has been ap...

Anaplastic thyroid carcinoma (ATC) is an uncommun and highly aggressive malignancy. Differentiated follicular and papillary thyroid carcinomas account for most (80-90%) thyroid malignancies with ATC accounting for less than 5%. A diagnosis of ATC is usually fatal with a mean survival of 3-9 months and only 10-15% alive at 2 years. Histologic examination reveals that many of them contain a papil...