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Fibronectin (FN) mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion, migration, growth and differentiation (Mosher, 1989; Carsons, 1989; Hynes, 1990; Yamada and Clark, 1996). FN is widely expressed by multiple cell types and is critically important in vertebrate development, as demonstrated by the early embryonic letha...
The superfamily of dynamins includes classical dynamins and dynamin-related proteins. Classical dynamins are proteins that share sequence similarity with the first described dynamin, which is a large GTPase with five characteristic domains. Dynamin-related proteins differ from classical dynamins in that they contain, at a minimum, three of the five characteristic domains. Dynamins are associate...
Individuals with upper-limb amputations may currently use artificial limbs controlled with signals from their residual muscles. Pattern recognition, one type of advanced control, uses the patterns produced by several muscles to control prosthesis movements. This article describes a new way to test this control by using a virtual environment performance test called the Target Achievement Control...
These computational models are at the core of collisional plasma theories. In particular we will discuss several aspects of conservative solvers for the kinetic transport equations of particle interactions that involve either linear or non-linear Boltzmann as well as the non-linear Landau equations, by means of stagger conservative DG schemes for the transport part and DG or spectral solvers fo...
Cells can contact the extracellular matrix (ECM) through a variety of specialized structures. These cell-matrix contacts contain membrane proteins such as integrins, which bind both matrix components and cellular proteins, thus bridging the substratum and the cytoskeleton (reviewed in Adams, 2001). Matrix contacts provide the physical linkage that enables cells to adhere to and migrate on (or t...
Ankle performance and function assessment during robot-assisted therapy is crucial for an effective ankle rehabilitation strategy. Existing assessment techniques can be categorized into qualitative and quantitative methods. However, little is known about the effectiveness of existing ankle assessment techniques for potential use in robot-assisted therapy. This article provides a comprehensive r...
The protein kinase C (PKC) family is represented in all eukaryotes and in Homo sapiens comprises the related PKCα through PKCι gene products (Dempsey et al., 2000). The kinase domains are closely related, as illustrated in the dendrogram, and form part of the AGC kinase superfamily. For clarity, the PKC-related kinases (PRK/PKN) are not included here; similarly excluded is the PKD/PKCμ family, ...
Over 12 mo following their initial evaluation, Veterans screening positive on a traumatic brain injury (TBI) clinical reminder had over 85 percent higher total costs than Veterans who screened negative. Understanding healthcare utilization and cost patterns following TBI screening is important for policymakers as they address the ongoing and future healthcare needs of returning Operation Iraqi ...
Ran is an abundant Ras-like GTPase that was initially characterized for its role in modulating the nucleo-cytoplasmic transport of macromolecules across the nuclear envelope (NE). However, it is also critical for other cellular processes, including mitotic spindle assembly and post-mitotic nuclear envelope assembly. Several excellent reviews detail its role in these diverse processes (Gruss and...
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