This review focuses on rapid and reversible noncovalent interactions for symmetric oligomers of signalling proteins. Symmetry mismatch, transient symmetry breaking and asymmetric perturbations via chemical (ligand binding) and physical (electric or mechanic) effects can initiate the signalling events. Advanced biophysical methods can reveal not only structural symmetries of stable membrane-boun...

We present a particle separation mechanism which induces the motion of particles of different sizes in opposite directions. The mechanism is based on the combined action of a driving force and an entropic rectification of the Brownian fluctuations caused by the asymmetric form of the channel along which particles proceed. The entropic splitting effect shown could be controlled upon variation of...

An analytical compact model for the asymmetric lightly doped Double Gate (DG) MOSFET is presented. The model is developed using the Lambert Function and a 2-dimensional (2-D) parabolic electrostatic potential approximation. Compact models of the net charge and channel current of the DGMOSFET are derived in section 2. Results for the channel potential and current are compared with 2-D numerical ...

This paper aims to examine the nature of width, depth and configuration distribution along Kuya River and their temporal directionality of changes. It also pays attention to prepare some simplified indices regarding basin asymmetry, channel asymmetry and river bank stability and to explain the nature of basin and channel asymmetry and river bank stability using those constructed indices. Irregu...

We determine analytic expressions for the performance of some low-complexity combined source-channel coding systems. The main tool used is the Hadamard transform. In particular, we obtain formulas for the average distortion of binary lattice vector quantization with affine index assignments, linear block channel coding, and a binary-symmetric channel. The distortion formulas are specialized to ...

From the customer perspective, Business-to-Customer (B2C) is to be defined as a channel. In order to survive, grow, and succeed, IS managers should design B2C channels with attributes that maximize customer satisfaction. The authors investigate B2C channel attributes as antecedents for customer satisfaction. The relationship between the attribute-level performance and overall satisfaction is al...

The peristaltic flow of a Prandtl fluid in an asymmetric channel has been investigated both analytically and numerically. This is the first article describing feature of Prandtl fluid model in peristaltic literature. The governing equations for the proposed Prandtl fluid model are derived in Cartesian coordinates system. Asymmetric channel have been taken into account for the present analysis. ...

A finite number of users communicating through a broadcast channel is considered. Each user has a buffer of infinile capacity, and a user randomly accesses the channel ( ALOHA-type protocol). Moreover, only one packet per user might be sent in an access time. Both symmetric and asymmetric models are considered, that is, we assume either indistinguishable or distinguishable users. An exact analy...

ATP hydrolysis by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel predicts that energy from hydrolysis might cause asymmetric transitions in the gating cycle. We found that 3-( N-morpholino)propanesulfonic acid (MOPS) blocked the open channel by binding to a site 50% of the way through the electrical field. Block by MOPS revealed two distinct states, O1 and O2, which ...

We report a systematic computational search of molecular frameworks for intrinsic rectification of electron transport. The screening of molecular rectifiers includes 52 molecules and conformers spanning over 9 series of structural motifs. N-Phenylbenzamide is found to be a promising framework with both suitable conductance and rectification properties. A targeted screening performed on 30 addit...