asthma and  gastroesophageal reflux disease (gerd)  are two  common  problems  in pregnancy and they affect pregnancy in several ways. in this study, we aimed to evaluate gerd and asthma in pregnant women who referred for prenatal care visits. one-hundred  and seventy three  pregnant  women with a complaint of  dyspnea were included in the study. a questionnaire was filled and lung function tes...

BACKGROUND Respiratory viral infections can induce different cytokine/chemokine profiles in lung tissues and have a significant influence on patients with asthma. There is little information about the systemic cytokine status in viral respiratory-infected asthmatic patients compared with non-asthmatic patients. OBJECTIVES The aim of this study was to determine changes in circulating cytokines...

Background: The prevalence of asthma varies among different regions based on the presence risk factors. Second-hand smoking is one factors that leads to an increased prevalence, exacerbation, and poor control asthma. Thereby, this study aimed investigate children impact second-hand patients. Methodology: This cross-sectional included parents in Saudi Arabia. It was conducted during period from...

Asthma and eosinophilia are two closely related pathologies whose interaction is key in the era of precision medicine. However, this relationship rarely taken into account without influence therapeutic prescriptions. In study involving 1296 subjects, between asthma was analyzed taking other biases. We observed that rhinitis only appears non-asthmatic patients with elevated blood eosinophil leve...

Asthmatic bronchial smooth muscle (BSM) is characterized by structural remodeling associated with mast cell infiltration displaying features of chronic degranulation. Mast cell-derived tryptase can activate protease activated receptor type-2 (PAR-2) of BSM cells. The aims of the present study were (i) to evaluate the expression of PAR-2 in both asthmatic and non asthmatic BSM cells and, (ii) to...

The prevalence of allergic diseases such as asthma has increased markedly over the past few decades. To evaluate the possible mutual influence of helminth infection and allergy, the combined effects of experimental allergic airway inflammation and infection with Strongyloides venezuelensis on various parasitological and inflammatory indices were evaluated in the rat. A challenge of immunized ra...

AIM to investigate the spirometric response to the exercise challenge in asthmatic and non-asthmatic obese children. PATIENTS, MATERIALS AND METHODS it was a prospective, longitudinal, open label clinical trial with four groups of children from 8 to 16 years. The group 1 had 15 asthmatic non-obese children. The group 2 had 15 asthmatic obese children. The group 3 had 15 non-asthmatic obese ch...

Although both asthmatics and allergic rhinitics develop an acute inflammatory response to lower airway allergen challenge, only asthmatics experience airway obstruction resulting from chronic environmental allergen exposure. Hypothesizing that asthmatic airways have an altered response to chronic allergic inflammation, we compared the effects of repeated low-level exposures to inhaled Alternari...

In the present investigation, we have studied the bronchoprotective effect of ethanolic extract of Achyranthes aspera Linn. in toluene diisocyanate (TDI) induced occupational asthma in wistar rats. Wistar rats were divided into four different groups of eight animals each. All animals except control group were sensitized by the intranasal application of 10% TDI to induce airway hypersensitivity....

Inhalation of adenosine causes bronchoconstriction in asthmatic subjects, but the effect of this purine nucleotide on airway vascular permeability is unknown. In order to determine whether adenosine produces airway microvascular leakage and, if so, to examine the effect of cromolyn (sodium cromoglycate (SCG)) on this extravasation of Evans blue was measured in the airways of ovalbumin-sensitize...