CRP is a marker of inflammation and increased levels have been associated with aging, smoking, cardiovascular diseases, connective tissue disorders and chronic obstructive pulmonary disease (COPD). Asthma is defined as a state of chronic inflammation where various cellular elements are involved. It is reasonable to expect elevated CRP levels in this chronic inflammatory disease. Hs-CRP assays a...

The purpose of the study — to identify and evaluate clinical significance “hidden” disorders blood oxygenation in smokers with exacerbation bronchial asthma. Materials methods: spirometry, pulse oximetry, CO-metry exhaled air. To diagnose oxygenation, including violations spectral characteristics level hemoglobin oxygen saturation, 19 male (middle age 54,6±2,05 years) mixed (68 %) or allergic (...

Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted. Ge...

BACKGROUND The adverse effects of long term treatment of asthma with the short acting beta agonist fenoterol have been established in both epidemiological and clinical studies. A study was undertaken to investigate the efficacy and safety of long term treatment with salbutamol and salmeterol in patients with mild to moderate bronchial asthma. METHODS In a two centre double dummy crossover stu...

Oxidative stress has been implicated in the pathogenesis of asthma. We aimed at investigating the biomarkers of oxidative stress, inflammation, and tissue damage in patients with asthma in acute exacerbation and remission. We recruited 18 asthmatics admitted to hospital with acute exacerbation and 18 healthy nonsmoking controls matched for age. We evaluated plasma levels of 8-isoprostane, C-rea...

INTRODUCTION Asthma with adult onset and elevated blood eosinophils is a difficult-to-treat subgroup. This post hoc analysis evaluated reslizumab, an anti-interleukin-5 monoclonal antibody, in patients with late-onset eosinophilic asthma. METHODS Data from two 52-week placebo-controlled trials of reslizumab IV 3 mg/kg every 4 weeks in patients aged 12-75 years with inadequately controlled ast...

Effects of vitamin D on acute exacerbation, lung function, and fraction of exhaled nitric oxide (FeNO) in patients with asthma are controversial. We aim to further evaluate the roles of vitamin D supplementation in addition to asthma controllers in asthmatics. From 1946 to July 2015, we searched the PubMed, Embase, Medline, Cochrane Central Register of Controlled Trials, and ISI Web of Science ...

Introduction: Countries like Bangladesh have seen an increase in the prevalence of bronchial asthma. The goal study was to compare efficacy nebulized salbutamol and epinephrine treating children with acute Objectives: To assess clinical improvement asthma following nebulization epinephrine. Methodology: This random, double-blind trial conducted paediatric department Mymensingh Medical College H...