We report a case of a 42-year-old woman with systemic lupus erythematosus and chronic kidney disease stage 5 undergoing continuous ambulatory peritoneal dialysis, presenting asthenia, dizziness, abdominal pain and small efforts dyspnea. After a complete physical and clinical examination, including laboratory tests, esophagogastroduodenal endoscopy and gastric lesions biopsy, she was diagnosed w...

Craving is an uncontrollable impulse to assume abusive substances, often associated with intense anxiety, dysphoria, irritability, agitation, impulsive or explosive behaviours, as well as with somatic symptoms such as headache and asthenia. Craving can be separated into two components: an ‘appetitive craving’, that is searching for the abusive substance as a source of pleasure, and an ‘aversive...

We report miscarriage following dengue virus (DENV)-3 infection in a pregnant woman returning from Bali to Italy in April 2016. On her arrival, the woman had fever, rash, asthenia and headache. DENV RNA was detected in plasma and urine samples collected the following day. Six days after symptom onset, she had a miscarriage. DENV RNA was detected in fetal material, but in utero fetal infection c...

A 32-year-old male was evaluated in the emergency epartment for worsening asthenia, dizziness, headache and hotophobia for the past five days. Physical examination evealed purple and brown lesions in the inner thigh and enis, suggestive of cutaneous Kaposi’s sarcoma (KS). His ast medical history was remarkable for acquired immunoeficiency syndrome (AIDS) diagnosed five years before with rratic ...

Section Edition: Alfredo José Mansur ([email protected]) Associated Editors: Desidério Favarato ([email protected]) Vera Demarchi Aiello ([email protected]) The patient started to present shortness of breath, which initially appeared at great efforts and progressed until it was also triggered by mild efforts. Fatigue and asthenia were associated to this picture. Four months before...

Introduction Interleukin-36-receptor antagonist deficiency (DITRA) is a recently described auto-inflammatory disease, characterized by repeated flares of generalized pustular psoriasis, high fever, asthenia and systemic inflammation. This condition is caused by homozygous missense mutation in the IL36RN gene, encoding the interleukin-36-receptor antagonist (IL-36Ra), an anti-inflammatory cytoki...

A 37-year-old Panamanian woman who had been resident in Spain for 18 years presented in the emergency department with a febrile syndrome that had begun 7 days earlier, after her return from a 2-week trip to Panama. Symptoms included intense headache predominantly behind the eyes, joint and muscle pain, and asthenia. At 24 hours she developed a rash on the lower limbs associated with plantar dys...

An outbreak of dengue fever in Madeira island was reported in 2012. Clinical and laboratory findings of the first two laboratory-confirmed autochthonous cases are reported. Both cases had fever (≥38 °C) and petechial rash. Symptoms also included myalgia, asthenia, nausea, vomiting, anorexia, diffuse abdominal pain, and diarrhoea. The two cases were confirmed by serology and one tested positive ...

We report the case of a six-year-old Brazilian girl referred for splenomegaly who first presented with fever, asthenia, and weight loss. Geographical location, clinical exam, and blood laboratories suggested kala-azar. Serology confirmed kala-azar diagnosis, but direct evidence of the parasites was not made. A treatment by meglumine antimoniate is given under hospital surveillance for two weeks...