Multiple sclerosis is a chronic demyelinating disease affecting one million people worldwide, with a significant burden of psychiatric comorbidity. Depression is the commonest psychiatric manifestation but still remains largely underdiagnosed and undertreated. The present work reviews current knowledge on diagnosis, assessment, and somatic and psychotherapeutic treatment interventions for depre...

vitamin d has long been speculated to reduce the risk of multiple sclerosis (ms). however, its role in development and modulating the course of ms has yet to be clarified. to date, there is no scientific evidence for the use of vitamin d as monotherapy for ms in clinical practice and perplexities still exist on potential disadvantages of vitamin d intake. we hypothesize that vitamin d may be ef...

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background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

background: there has been a global rising trend in recent years in the incidence of multiple sclerosis (ms). despite being an ms low-risk region, this disease has also been recently on the rise in the middle east. as part of the middle east, iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. the present study reviews possible reasons for thi...

conclusions the orem-based self-care model program can be a useful tool to improve sleep quality of patients with ms. future studies can be directed to investigate the effects of such interventions on other common problems of patients. results before the intervention, there was no significant difference between the two groups with regard to mean scores of sleep quality (p = 0.22). both groups r...

multiple sclerosis (m.s) is one of the prevalent diseases of the central nervous system which cause disability in young adults. this appears as neural signs in different parts and various times. the main defect is local deterioration or destruction of myelin tissue in the brain and spinal cord. profound fatigue is one the most common symptoms of this disease. because ms is prevalent in middle a...

abstract objective: according to the previous studies, 2-5 percent of patients with multiple sclerosis experienced the first episode of disease before the age 16.  since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. this study aims to determine the epidemiological and clinical patterns of ms among iranian child...

conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...