conclusions it seems that surrogate liver function tests and adipocytokine levels were correlated with the histologic findings of the liver. objectives the aim of the study was to evaluate the correlation between serum adipocytokines and the histologic findings of the liver in patients with non-alcoholic fatty liver disease (nafld). patients and methods this case-control study was performed on ...

BACKGROUND Non-alcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease. Several studies suggest that pentoxifylline (PTX) can improve the disease outcome. OBJECTIVES We aimed to compare the effect of pentoxifylline with placebo on liver aminotransferases and cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin 8 (IL...

Cancer cells exhibit metabolic dependencies that distinguish them from their normal counterparts. Among these addictions is an increased utilization of the amino acid glutamine (Gln) to fuel anabolic processes. Recently, we reported the identification of a non-canonical pathway of Gln utilization in human pancreatic cancer cells that is required for tumor growth. While most cells utilize glutam...

OBJECTIVE This retrospective study investigated abnormal hepatic dysfunction and abdominal computed tomography (CT) findings in scrub typhus. METHODS Three hundred forty nine adult patients were diagnosed with scrub typhus. Ninety four underwent abdominal CT. The CT images were reviewed by the attending radiologist. Patient data of history, symptoms, signs, and results of laboratory tests wer...

The prevalence of alcoholic liver disease and non-alcoholic patients has nearly doubled over the past decades worldwide. Alcoholic among with chronic increased arisen due to alcohol consumption obesity. diagnosis plays a crucial role in treating such conditions based on stages functioning. elevated enzymes are key characterizing identifying (ALD) NAFLD. Later on, there is progression by develop...

Case presentation: VTG, 2 years old, daughter of non-consanguineous parents, born by cesarean section at 35 weeks. At birth, he had neonatal sepsis and hypoglycemia. 3 months, started generalized tonic-clonic seizures associated with behavioral arrest ocular version, refractory to treatment optimization antiepileptic drugs. In addition neuropsychomotor developmental regression, sleep disturbanc...

1. A vitamin &-deficient diet was fed to an adult male subject to confirm previously described changes in tryptophan metabolism and urinary 4-pyridoxic acid excretion, and erythrocyte alanine and aspartate aminotransferase activities. 2. The results were compared with those obtained in women taking oestrogencontaining oral contraceptives. 3. The development of dietary vitamin B, deficiency was ...

1. The single (cytosolic) aspartate aminotransferase was purified in high yield from baker's yeast (Saccharomyces cerevisiae). 2. Amino-acid-sequence analysis was carried out by digestion of the protein with trypsin and with CNBr; some of the peptides produced were further subdigested with Staphylococcus aureus V8 proteinase or with pepsin. Peptides were sequenced by the dansyl-Edman method and...

We reviewed the literature regarding the serum levels of the enzymes aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase in patients with chronic kidney disease on hemodialysis with and without viral hepatitis. Original articles published up to January 2013 on adult patients with chronic kidney disease on hemodialysis were selected. These articles contained the ...

Specific amino acids are known to acutely and chronically regulate insulin secretion from pancreatic -cells in vivo and in vitro. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to exocytosis of insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP, which is the main coupli...