Among several sympathomimetic drugs, isoproterenol, epinephrine and norepinephrine significantly potentiated the cytotoxic effect and the uptake of MMC into rat ascites hepatoma AH130 cells in in vitro experiments, but salbutamol, tulobuterol and phenylephrine did not. The enhancement of MMC uptake into AH130 cells by isoproterenol and norepinephrine was diminished by propranolol but not by phe...

The enzyme carbamyl phosphate-aspartate transcarbamylase catalyzes the transfer of the carbamyl group from carbamyl phosphate (CP) to L-aspartate ($). Preliminary experiments with a series of six relatively advanced azo dye-induced hepatomas indicated that hepatoma tissue had a higher CP-aspartate transcarbamylase activity than did liver from normal animals. Experiments are reported here in whi...

We previously identified a G-rich silencer element involved in negative regulation of catalase gene expression in some hepatoma cells (Mol. Cell. Biol., (1992), 12, 2525-2533). To study a nuclear binding protein for this element, we screened cDNA libraries from a rat ascites hepatoma cell line by binding with a synthetic oligonucleotide probe and obtained several clones. One of them, designated...

i Letter to the Editor. 483 Controlling Factors in Urethan Carcinogenesis in Mice: Effect of Enzyme Inducers and Metabolic Inhibitors. Richard S. Yamamoto, John H. Weisburger, and Elizabeth K. Weisburger. 487 Isolation and Partial Characterization of a Glyceraldehyde 3-Phosphate Dehydrogenaseinactivating Factor from Ehrlich Ascites Tumor Cells. Francisco P. Marnarli and Saul Green. 491 Absence ...