نتایج جستجو برای: as2o3

تعداد نتایج: 328  

2017
Tao Feng Jun Xu Ping He Yuanyuan Chen Ruiying Fang Xuejun Shao

Osteosarcoma (OS) is the most common type of malignant bone tumor in children and adolescents. In total, 40-50% of patients with OS experience metastasis, and thus have a poor prognosis. Our previous study demonstrated that arsenic trioxide (As2O3) combined with doxorubicin [also known as Adriamycin (ADM)] significantly inhibited OS cell proliferation by downregulating stathmin expression. The ...

Journal: :Sains Malaysiana 2022

Arsenic (As) is a bioactive metalloid that highly toxic to humans, animals, and plants. Environmental contamination of As especially in groundwater increases due natural anthropogenic activities. The present study was performed evaluate the potential wild Tagetes species for phytoremediation contaminated soil/water. This comparative research aims analyze accumulation tolerance two Tagetes, T. m...

Journal: :Blood 2005
Nicos Karasavvas Juan M Cárcamo George Stratis David W Golde

Although there is no compelling evidence that vitamin C has antitumor activity in humans, clinical trials are testing the hypothesis that ascorbic acid (AA) will enhance the efficacy of arsenic trioxide (As2O3) in myeloma. In vitro, AA cytotoxicity depends on its interaction with free transition metal ions in culture media leading to the generation of H2O2 and other reactive oxygen species (ROS...

Journal: :Acta poloniae pharmaceutica 2007
Ramtej Verma Mrugesh Trivedi Heena Keshwani Pooja Choksi Neha Sangai

The ameliorative effect of the aqueous extract of three medicinal plants P. fraternus. Terminalia A., and Moringa oleifera (PF, TA, and MO) on arsenic trioxide (As2O3) induced alteration in lipid peroxidation (LPO) and protein contents was studied in vitro. Liver from healthy chicken (Gallus domesticus) weighing 1.2 to 1.5 kg was bought to laboratory in frozen condition from local slaughter hou...

Journal: :Oncology reports 2008
Jung-Hyun Park Eun-Jung Kim Hye-Yeon Jang Heyok Shim Kang-Kyoo Lee Hyang-Jeong Jo Hwi-Jung Kim Sei-Hoon Yang Eun-Taik Jeong Hak-Ryul Kim

Arsenic trioxide (As2O3) has been introduced to the treatment of acute promyelocytic leukemia (APL), and has also been shown to induce apoptosis in a variety of solid tumor cell lines, including non-small cell lung cancer. However, the prohibitively high concentration required for the induction of apoptotic cell death in many solid tumor cells is unacceptable for clinical utilization due to the...

Journal: :Oncology reports 2010
Hai-Ying Fu Jian-Zhen Shen Yong Wu Song-Fei Shen Hua-Rong Zhou Li-Ping Fan

Cyclin-dependent kinase inhibitors CDKN2B and CDKN2A are tumor suppressor genes that are frequently dysregulated in a variety of cancers. Aberrant regulation via DNA hypermethylation causes gene silencing. Arsenic trioxide has been successfully used to treat malignant, hematopoietic diseases and is known to act by induction of apoptosis and inhibition of cellular proliferation. However, arsenic...

2018
Zilong Hu Shidong Hu Youjun Wu Songyan Li Changzheng He Xiaowei Xing Yufeng Wang Xiaohui Du

Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by various tumor escape mechanisms, including the accumulation of immunoregulatory cells. As a result of peritoneal metastasis in the terminal stage, malignant asci...

2006
Pierre Bobé Danielle Bonardelle Karim Benihoud Paule Opolon Mounira K Chelbi-Alix

MRL/lpr mice develop a human-lupus-like syndrome and, as in autoimmune lymphoproliferative syndrome (ALPS), massive lymphoproliferation due to inactivation of Fas-mediated apoptosis. Presently, no effective therapy exists for ALPS, and long term, therapies for lupus are hazardous. We show herein that arsenic trioxide (As2O3) is able to achieve quasi-total regression of antibodyand cell-mediated...

Journal: :Biocell 2022

Sphingosine kinase 1 (SphK1) is an important synthetase during the synthesis of sphingosine-1-phosphate (S1P) from sphingosine (Sph). Previous studies demonstrated that arsenic trioxide (As2O3) could reduce level S1P in human gastric cancer cell line MGC-803, indicating As2O3 may inhibit activity SphK1. In this study, effect on SphK1 activation pathway was investigated. Western blot and quantit...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد تهران مرکزی - دانشکده علوم پایه 1390

سرم آلبومین انسانی (hsa) یک پروتئین اصلی برون سلولی با غلظت بالا در پلاسمای خون بوده و حامل بسیاری از داروها برای رسیدن به هدف های مولکولی متفاوت می باشد. سرم آلبومین انسانی با سایت های مناسب اتصال و ویژگی پیوندی بالا، یک عامل انتقال دهنده برای انتقال ترکیبات متعدد و داروها در داخل بدن می باشد . اتصال داروها به سطح hsa می تواند ویژگی های بیوفیزیکی و بیوشیمیایی این پروتئین را تغییر دهد. امروزه د...

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