Abstract Objectives The current research examines the protective effects of Piper cubeba ethanolic extract and its isolated lignans; Cubebin Hinokinin fractions against Alzheimer’s Disease (AD) in vitro model. Methods Dried powdered fruit P. were extracted ethanol fractionated using silica gel column chromatography. Of 15 eluted fractions, two indicated presence targeted Lignans; Cubebin. They ...

Linum spp. (Linaceae) has been shown to accumulate cytotoxic lignans such as podophyllotoxin and 6-methoxypodopyllotoxin. Therefore, plant cell and tissue cultures of Linum spp. may be possible alternative sources for the lignan production. In this study, we focused on the production of lignans by root cultures of Linum spp. Hairy root cultures of L. nodiflorum, L.album and L. austriacum and ro...

Abstract We developed and validated an optimized method for quantifying lignans using ultra-performance liquid chromatography (UPLC) performs correlation analysis of growth characteristics contents lignans. The methods determining were by measuring the linearity, limit detection (LOD), quantification (LOQ), accuracy, precision UPLC. All calibration curves showed good linearity ( r 2 ≥ 0.9998) w...

The Paraguayan crude drug "tayï pytá" is used to treat cancer, wounds and inflammation. It consist of the bark and trunkwood of Tabebuia heptaphylla (Bignoniaceae). A phytochemical study of the crude drug gave, in addition to previously described naphthoquinones and the known lignans cycloolivil and secoisolariciresinol, three new lapachenol (lapachonone)-, two naphthofuran-, a chromone and a n...

− Pancreatic lipase digests dietary fats by hydrolysis, which is a key enzyme for lipid absorption. Therefore, reduction of fat absorption by the inhibition of pancreatic lipase is suggested to be a therapeutic strategy for obesity. We previously reported coumarins and secoiridoids of Fraxinus rhynchophylla as inhibitory constituents on adipocyte differentiation. Further investigation on F. rhy...

Phytochemical investigation of an ethanolic extract of stems of Schisandra neglecta led to the isolation and identification of two new dibenzocyclooctadiene lignans, designated neglschisandrins E (1) and F (2), and thirteen known lignans. All structures and stereochemistries were determined by spectroscopic methods, including 2D-NMR techniques. The isolates were evaluated for in vitro cytotoxic...