Patients with recessive dystrophic epidermolysis bullosa (RDEB) develop multiple skin wounds that heal extensive scarring, contractures, and mitten deformities. RDEB patients display increased pro-fibrotic TGF-β signaling, a distinct gene expression profile, elevated inflammation genes. No specific pharmacological treatment is currently available for fibrosis. Artemisinin its derivatives are an...

Renal cell carcinoma (RCC) is the third most common genitourinary malignancy, accounting for 3% of cancer in adults. The mortality and morbidity of RCC is strongly associated with its high propensity to metastasize to specific organs. This may be attributed to the fact that the CXCR4 G protein-coupled receptor (GPCR) on RCC cells mediates chemoatt...

5 6 Dirk Grimm, Joyce S. Lee, Lora Wang, Tushar Desai, Bassel Akache, Theresa A. 7 Storm, and Mark A. Kay 8 9 10 Stanford University, School of Medicine, Departments of Pediatrics and Genetics, 300 11 Pasteur Drive, Department of Biochemistry, 279 Campus Drive, Stanford, California, 12 94305, USA 13 #Current address: University of Heidelberg, Cluster of Excellence CellNetworks, 14 BIOQUANT, Im ...

This paper presents some new results on numerical stability for various fast trigonometric transforms. In a worst case study, we consider the numerical stability of the classical fast Fourier transform (FFT) with respect to different precomputation methods for the involved twiddle factors and show the strong influence of precomputation errors on the numerical stability of the FFT. The examinati...

It is demonstrated experimentally and theoretically that through the use of an active (feedback) controller one can dramatically modify the nature of the flow in a toroidal thermal convection loop heated from below and cooled from above. In particular, we show how a simple control strategy can be used to suppress (laminarize) the naturally occurring chaotic motion or induce chaos in otherwise t...

Perlmutter (1970) argued that the indefinite article is categorically different from the definite article and proposed that it is a clitic version of the numeral "one". But there are, as Perlmutter himself pointed out, instances of "a" as well as of "one" that don't seem to have the semantics of the numeral. Hence a divorce of "a" (and of "one") from "numeral"-hood is called for. Furthermore, t...

A common assumption underpinning health communications design in humanitarian settings is that increasing knowledge and risk perception will lead to appropriate behaviour change. This study compares associations of HIV knowledge and perceived risk with reported HIV-avoidant behaviour changes and sexual health choices from a community survey of 698 sexually experienced male and female Sierra Leo...

The vast majority of the world's population is infected with HSV. Although antiviral therapy can reduce the incidence of reactivation and asymptomatic viral shedding, and limit morbidity and mortality from active disease, it cannot cure infection. Therefore, the development of an effective vaccine is an important global health priority. In this study, we demonstrate that recombinant Listeria mo...

The study reported in this article investigated the linguistic challenges that students face at an English medium instruction (EMI) university Turkey. aims of were (1) to describe experience their EMI classes; (2) investigate how these vary according individual student characteristics; and (3) validate a research instrument designed explore academic language-related contexts. Data collected fro...