Background: Kaykhosrow is one of the prominent kings in Shahnameh who, after coming to power, has taken favorable measures for the growth and excellence of Iranian society. One of his challenges in governing the country was the border conflicts by the Turanians, which caused many problems. However, in dealing with the main enemies of the Iranians, Kaykhosrow has not always been alienated from m...

Electronic Patient Record Systems (EPRS) hold an exceptional position in the field of Medical Informatics. The aim of such systems is to replace the traditional paper-based patient recording, offering at the same time a set of advanced data exchange functionalities modern computers and networks can offer. ARISTOPHANES is a flexible and efficient EPRS, designed to serve surgery wards. This paper...

1050 NOTICES OF THE AMS VOLUME 46, NUMBER 9 T his year marks the thirtieth anniversary of the realization of the dream of one Swedish mathematician. In 1916, on his seventieth birthday, Gösta Mittag-Leffler promised his and his wife’s considerable fortune to the goal of founding a mathematics institute. More than forty years had to pass after his death before the institute was launched in earne...

The style of scientific giants differs at least as much as their interests. Seymour Benzer, who died in Pasadena on Novem-ber 30, 2007, at the age of 86, was made of the stuff of the great restless explorers. But unlike the Cooks and Magellans, he never waited for a monarch's approval to sail, nor did he claim sovereignty over the new territory. With admirable drive, curiosity , and tenacity, h...

Single-stranded DNA (ssDNA)-binding proteins play an essential role in DNA replication and repair. They use oligonucleotide/oligosaccharide-binding (OB)-folds, a five-stranded β-sheet coiled into a closed barrel, to bind to ssDNA thereby protecting and stabilizing the DNA. In eukaryotes the ssDNA-binding protein (SSB) is known as replication protein A (RPA) and consists of three distinct subuni...

A gene encoding an endopeptidase from Streptococcus parasanguis FW213 has been cloned and shown to have high sequence homology to genes encoding mammalian metalloendopeptidases. The gene, designated S. parasanguis pepO, was cloned into the pET28a expression vector, resulting in a fusion of vector sequences encoding a hexahistidine tag at the carboxyl terminus. The recombinant PepO (rPepO) was e...

We previously showed that a fungal protein, p15, induces neurite outgrowth and differentiation of rat pheochromocytoma PC12 cells. We report here the identification and characterization of a protein similar to p15, found in Streptomyces coelicolor A3(2). This hypothetical protein, tentatively named Scp15, has significant similarity with p15, including conserved positions of four cysteine residu...

Fluorescent indicators that allow real-time imaging of Zn(II) in living cells are invaluable tools for understanding Zn(II) homeostasis. Genetically encoded sensors based on fluorescence resonance energy transfer between fluorescent protein domains have important advantages over synthetic probes. We discovered that hexahistidine tags have a strong tendency to dimerize upon binding of Zn(II) in ...