The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

A chitosan gel additive modulates the initial vaterite dissolution–recrystallisation in injectable aragonite-based composite cement and promotes its vitro bioactivity.

PURPOSE Carbamazepine is a poor water soluble drug and its bioavailability is limited by dissolution rate. Dissolution, serum concentration and anticonvulsive effect of the drug have been evaluated after cogrinding with microcrystalline cellulose. A cogrinding technique was used to increase the dissolution, serum concentrations and anticonvulsive effect of the drug. A novel deconvolution techni...

Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and bioavailability of orally administered drugs, and to identify solubility limitations and stability issues. To develop a biorelevant dissolution t...

In vivo dissolution of crystalline insulin formulations is an important step for insulin absorption in the subcutaneous therapy of diabetes, which is the most widespread. Here, data on the in vitro dissolution of three different crystalline forms of commercial porcine insulin are reported. The aim of this study was to create a model framework of in vivo dissolution of insulin crystalline formul...

Objective: The objective of the present investigation was to improve dissolution characteristics of EZE, which might offer improved bioavailability. Method: The solid dispersion of Ezetimibe was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, Sodium starch glycolate). The tablets were prepared by direct compression method. The compressed t...

The most common pharmaceutical formulations for antibiotics are the tablets and hard gelatin capsules. The typical shelflife of these dosage forms is five years. In the most countries of the world it is required by the law that the expired medications have to be disposed following the respective regulations. Furthermore, it is common sense not to use the expired medications. The present study w...

Objective: Chlorzoxazone (CLZ) is centrally acting skeletal muscle relaxant. It is insoluble in water, so employed for the formation of solid dispersions (SD) as a means to enhance the dissolution rate, and carrier selected was polyethylene glycol 6000 (PEG 6000). Methods: The SDs were prepared by different methods and characterized by in vitro drug release, drug content, fourier transform infr...

the in vitro dissolution of plasma-sprayed hydroxyapatite (pha) coatings with different characteristics, produced by various spraying conditions, in a tris-buffered solution at ph 7.4 was experimentally studied through the measurement of calcium ions release with inductively coupled plasma atomic emission spectroscopy (icp-aes), and then modeled. three coating characteristics, the crystallinity...