Factor XII, (Hageman factor) is a serine protease zymogen that, when activated, initiates the intrinsic pathway of blood coagulation. Patients with Factor XII deficiency do not have excessive bleeding tendency despite prolongation of the activated partial thromboplastin time (APTT) in their serum. Postpartum Hemorrhage (PPH) is a potentially fatal obstetric complication, and its presence in the...

Heparin is administered as an anticoagulant in treatment of or prophylaxis against arterial or venous thromboembolism, in treatment of myocardial infarction, and during cardiac surgery (cardiopulmonary bypass) [1], coronary angioplasty, and other procedures [2]. Heparin treatment demands laboratory control and is monitored by determining the activated partial thromboplastin time (APTT), which s...

Thrombotic disorders increase the risk of cardiovascular/cerebrovascular complications and represent a major health problem worldwide. Anticoagulants are extensively used in treatment of these disorders. Vitamin K antagonists, like Warfarin, are frequently used in medication. Vascular calcification (VC) is a significant side-effect of vitamin K antagonists especially Warfarin. There is an urgen...

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monke...

INTRODUCTION Animal studies of acute lung injury (ALI) suggest nebulised heparin may limit damage from fibrin deposition in the alveolar space and microcirculation. No human studies have been undertaken to date. We assessed the feasibility, safety and potential anticoagulant effects of administration of nebulised heparin to patients with ALI. METHODS An open label phase 1 trial of four escala...

Effects of repeated administration ofphenobarbital (PB) on blood coagulation-related parameters were examined in non-pregnant, pregnant and lactating rats, and also in pups born to PB-treated lactating dams. PB was orally administered at a dose level of 80 mglkglday to pregnant (from gestation day (GD) 13), postpartum (from postpartum day (PPD) 7) and non-pregnant rats (from 13 weeks of age) fo...

To test recommended anticoagulation measures as predictors of 180-day venous thromboembolism (VTE) recurrence, we identified all Olmsted County, MN residents with incident VTE over the 14-year period of 1984-1997, and followed each case (N = 1166) forward in time for VTE recurrence. We tested the activated partial thromboplastin time (APTT), international normalized ratio (INR), and other measu...

Background: Coagulopathy is a common manifestation in cases of snake bite and its abnormality can be detected by blood coagulation tests. There are very few references in the literature related to coagulation parameter abnormalities after snake bite, evaluation of their seriousness and the length of the follow up period. Therefore we have undertaken this study to throw some light on the need of...

The effects of 3.2% and 3.8% sodium citrate concentration on the results of routine coagulation assays (prothrombin time [PT] and activated partial thromboplastin time [aPTT]) were evaluated by means of two sets of reagents, one responsive and the other nonresponsive. Five groups were entered in the study: healthy volunteers; outpatients receiving stable oral anticoagulant therapy; and hospital...

Safflower injection is well-known as a traditional Chinese medicine used to improve the blood circulation. In this study, seven safflower injection samples from different companies were evaluated for their in vitro anticoagulant activity by measuring their activated partial thromboplastin time (APTT) and prothrombin time (PT) against human plasma. The screening results suggested that the safflo...