Intravenous durvalumab (Imfinzi™; AstraZeneca) is a fully human monoclonal antibody that blocks programmed cell death ligand-1 binding to its receptors (PD-1 and CD80), resulting in enhanced T-cell responses against cancer cells. The US FDA has granted durvalumab accelerated approval for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progress...

Emperical studies have shown that interprocedural heap liveness analysis can be used to significantly improve garbage collection, thereby reducing memory consumption of programs. The main difficulty in achieving this goal is the unbounded nature of the heap, which makes it notoriously difficult to statically analyze using finite abstractions. A recent technique known as heap reference analysis ...