Despite numerous developed drugs based on glucose metabolism interventions for treatment of age-related diseases such as diabetes neuropathies (DNs), DNs are still increasing in patients with type 1 or type 2 diabetes (T1D, T2D). We aimed to identify novel candidates in adipose tissue (AT) and pancreas with T2D for targeting to develop new drugs for DNs therapy. AT-T2D displayed 15 (e.g. SYT4 u...

The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis. The RXR pathway plays a critical role in testicular lipid trafficking, and RXRbeta-deficient male mice are sterile and accumulate lipids in Sertoli cells. Here, we demonstrate t...

The APOLIPOPROTEIN (APO)A1/C3/A4/A5 gene cluster on chromosome 11 has been hypothesized to be a modifier of plasma triglycerides in FCH. In the present study, we extended previous association analyses of the gene cluster to include APOA5, a newly discovered member of the cluster. Eight SNPs across the APOA1/C3/A4/A5 gene region were analyzed in 78 FCH probands and their normolipidemic spouses a...

Objective: The purpose of this study was to explore the risk factors for Ocular metastasis (OM) Gastric cancer (GC). Methods: This is a retrospective cohort study. A total 1165 patients with GC were enrolled in and divided into OM non-ocular (NOM) groups. Chi-square independent samples t tests used determine whether differences demographic characteristics serological indicators (SI) between two...

Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role diseases such as atherosclerosis Alzheimer's. The major allele variants ApoE3 ApoE4 differ only by one amino acid. However, this difference has consequences for physiological behaviour each variant. In paper, we follow (i) initial interaction lipid-free ApoE with model mem...

Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides w...

Intrauterine growth restriction (IUGR) is one of the major causes of perinatal mortality and morbidity. Pregnancies with IUGR are associated with an altered lipid profile which in turn affects the fetal growth. The study was conducted on 60 age matched female individuals divided into three groups. Group A consisted of 20 normal pregnant women,Group B was formed by 20 women diagnosed as IUGR pre...

We highlight the various kinds of difficulties arising when comparing two sets of GO annotations using either the intersection of sets of annotations or semantic similarity measures. We illustrate our approach by comparing the GO annotations of Apolipoprotein A-5 (apoa5) and Apolipoprotein A-1 (apoa1) respectively between human (hsa) and mice (mmu). Apoa5 is involved in similar biological proce...

Many reports suggest that hepatic steatosis leads to hepatocellular carcinoma (HCC), including hepatitis C virus or non-alcoholic steatohepatitis. Proteomic study of tumor tissues from HCC patients, focusing on apolipoprotein (apo) of apoA1, apoB100 and apoE, was performed by immunoblotting. Although the significant changes of apoA1 or apoB100 could not be shown statistically, the immunoblottin...

Background Obesity and dyslipidemia are two common comorbidities in rheumatoid arthritis (RA). They considered as important cardiovascular atherosclerosis risk factors RA. Objectives The aim of our study was to evaluate the impact obesity on lipid parameters well atherogenic indexes among RA elderly patients. Methods A cross-sectional conducted including patients followed for aged ≥ 65 years. A...