BACKGROUND A reduced sensitivity for activated protein C (APC) is associated with an increased risk of venous thrombosis even in the absence of the factor (F)V Leiden mutation. This risk has been demonstrated with two APC sensitivity tests, which quantify the effects of APC on the activated partial thromboplastin time (APTT) and the endogenous thrombin potential (ETP), respectively. OBJECTIVE...

BACKGROUND Concern remains that ertapenem use may promote cross-resistance in Pseudomonas aeruginosa to antipseudomonal carbapenems (APCs). This study extends our earlier multicentre investigation of this relationship by an additional 3 years. METHODS Use density ratios (UDRs) for ertapenem, APCs, aminoglycosides, fluoroquinolones and non-carbapenem β-lactams were derived from purchase data f...

Women who are using oral contraceptives can acquire APC resistance, measured by the effect of APC on the endogenous thrombin potential (ETP). The objective of our study was to examine whether persistentAPC resistance determined with an ETP-based normalized APC sensitivity ratio (nAPCsr) is a risk marker for venous thromboembolism in women with pregnancy-associated thromboembolism. We determined...

We report the effect of homocysteine on the inactivation of factor Va by activated protein C (APC) using clotting assays, immunoblotting, and radiolabeling experiments. Homocysteine, cysteine, or homocysteine thiolactone have no effect on factor V activation by alpha-thrombin. Factor Va derived from homocysteine-treated factor V was inactivated by APC at a reduced rate. The inactivation impairm...

Low back pain (LBP) is one of the most important health conditions that can affect humans with physical and psychosocial changes. Non-specific LBP, defined as self-limiting whose exact cause cannot be determined, common among older adults. Lumbar disk herniation should first diagnosis comes to mind in 40–60-year-old patients clinical findings radiculopathy LBP. However, order not miss causes su...

Abstract A simple, stable, and high-sensitivity temperature sensor based on multimode interference in a polymer optical fiber (POF) with higher-order mode excitation has been developed. In single-mode–multimode–single-mode (SMS) structure, one end of the POF physical-contact (PC) connectors is connected to silica single-mode an angled-PC (APC) connector. We compare sensing characteristics three...