The selective glutamate metabotropic receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) was applied iontophoretically to cells in the rat primary somatosensory cortex (SI) in vivo. In contrast to other in vivo studies, distinct excitatory and depressant effects were observed. The excitatory responses could not be blocked by ionotropic antagonists, as evidence that t...

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Adenylyl cyclase (AC) modulation of vesicular cycling was visualized at cultured cerebellar granule cell synapses using the sequential uptake of antibodies directed against the intraluminal domain of synaptotagmin I. Vesicle recycling due to spontaneous transmitter release in the absence of action potentials was increased by the AC/protein kinase A (PKA) activators forskolin and CPT-cAMP. These...

Neuropeptide Y (NPY) has been shown to depress hyperexcitable activity that has been acutely induced in the normal rat brain. To test the hypothesis that NPY can also reduce excitability in the chronically epileptic human brain, we recorded intracellularly from dentate granule cells in hippocampal slices from patients with hippocampal seizure onset. NPY had a potent and long-lasting inhibitory ...

Neugebauer, Volker, N. Bradley Keele, and Patricia Shinnicklong-term effects of seizures, including intractable epilepsies Gallagher. Loss of long-lasting potentiation mediated by group and memory disorders (Sutula et al. 1995). III mGluRs in amygdala neurons in kindling-induced epileptogenThe G-protein coupled metabotropic glutamate receptors esis. J. Neurophysiol. 78: 3475–3478, 1997. Long-la...