Treatment of chronic hepatitis C with pegylated interferon-a and ribavirin is now adapted individually based on the virological response on treatment. This approach should improve the tolerability while maintaining or even improving in some patients the efficacy of antiviral therapy. Several new antiviral drugs are currently being evaluated in advanced clinical trials, with very promising resul...

Chikungunya virus, a re-emerging mosquito-borne alphavirus, causes fever, rash and persistent arthralgia/arthritis in humans. Severe outbreaks have occurred resulting in infections of millions of people in Southeast Asia and Africa. Currently there are no antiviral drugs or vaccines for prevention and treatment of chikungunya infections. Herein we report the current status of research on antivi...

HIV-1 integrase is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. A number of inhibitors have been reported in the past 8 years. This review focuses on the recent developments in the past 2 years. There are now several inhibitors with known sites of actions and antiviral activity. The challenge is to convert these leads into drugs that wi...

This article represents the second update to the AMMI Canada Guidelines document on the use of antiviral drugs for influenza. The article aims to inform health care professionals of the increased risk for influenza in long-term care facilities due to a documented mismatch between the components chosen for this season's vaccine and currently circulating influenza strains. Adjusted recommendation...

Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, is a cause of high morbidity and mortality rates among immunosuppressed individuals and patients with acquired immunodeficiency syndrome (AIDS). Despite the availability of approved antiviral drugs, treatment of HCMV infections remains difficult. Antiviral therapies are in part limited by the small number of available drugs sho...

Key issues in the development of novel antivirals are the emergence of resistant strains. The development of new drugs effective against herpes diseases has proven to be both difficult and time-consuming. Some alternative may be to optimize the efficacy and selectivity of existing antiviral drugs or combining them with other well known agents. Inosine pranobex exerts a direct antiviral effect a...

One of the most urgent problems our time is high morbidity and mortality people from viral infections, which can affect almost all organs systems host body. Significant damage to health population economy countries caused by incidence diseases. An important issue in process pharmacotherapy patients with infections provide them a sufficient number effective, safe affordable drugs, especially dur...

Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor can prevent aims of this project were evaluate the mechanism inhibited EV-A71 virus and provide experiment basis for finding new antiviral drugs. In study, after treated with in infected Vero cells, viral replication was reduced, cell viability higher than group. Additionally...