نتایج جستجو برای: antitumor bioactivity

تعداد نتایج: 44680  

Journal: :Circulation 2002
Senthil Kumar Venugopal Sridevi Devaraj Ivan Yuhanna Philip Shaul Ishwarlal Jialal

BACKGROUND C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis. METHODS AND RESULTS We tested the effect of CRP on eNOS expression and bioactivity in cultured human aortic endothelial cells (HAECs). CRP decreased eNOS mRNA...

Journal: : 2023

Introduction. Xanthone glycosides have unique structures and properties. Many efforts focus on the search for C-glycoside derivatives of mangiferin with higher bioavailability. The application QSAR approach allows optimization novel xanthone desired characteristics. Aim. Using available descriptors chemical structure, physical-chemical properties, biological activity, analyze a sample set known...

2012
Giovanni Vitale Michael P Brugts Giulia Ogliari Davide Castaldi Letizia M. Fatti Aimee J. Varewijck Steven W. Lamberts Daniela Monti Laura Bucci Elisa Cevenini Francesco Cavagnini Claudio Franceschi Leo J Hofland Daniela Mari Joseph A.M.J.L. Janssen

UNLABELLED Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total...

2011
Sunny Malhotra Marta F. Bustamante Francisco Pérez-Miralles Jordi Rio Mari Carmen Ruiz de Villa Esteban Vegas Lara Nonell Florian Deisenhammer Nicolás Fissolo Ramil N. Nurtdinov Xavier Montalban Manuel Comabella

Myxovirus A (MxA), a protein encoded by the MX1 gene with antiviral activity, has proven to be a sensitive measure of IFNβ bioactivity in multiple sclerosis (MS). However, the use of MxA as a biomarker of IFNβ bioactivity has been criticized for the lack of evidence of its role on disease pathogenesis and the clinical response to IFNβ. Here, we aimed to identify specific biomarkers of IFNβ bioa...

Journal: :American journal of physiology. Endocrinology and metabolism 2003
Jian-Wen Chen Thomas Ledet Hans Orskov Niels Jessen Sten Lund Jonathan Whittaker Pierre De Meyts Maj Britt Larsen Jens Sandahl Christiansen Jan Frystyk

At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by immunological measurements of IGF-I levels. However, immunoassays ignore the modifying effects of the IGF-binding proteins (IGFBPs) on the interaction between IGF-I and the IGF-I receptor (IGF-IR). Therefore, we developed an IGF-I kinase receptor activation assay (KIRA) based on cells transfected wit...

2014
Renny Mathew Baltzar Stevensson Antonio Tilocca Mattias Edén

The physiological responses of silicate-based bioactive glasses (BGs) are known to depend critically on both the P content (n(P)) of the glass and its silicate network connectivity (N(BO)(Si)). However, while the bioactivity generally displays a nonmonotonic dependence on nP itself, recent work suggest that it is merely the net orthophosphate content that directly links to the bioactivity. We e...

2017
Ceci Nunes Carvalho Renata Grazziotin-Soares George Táccio de Miranda Candeiro Luis Gallego Martinez Juliana Pereira de Souza Patrícia Santos Oliveira José Bauer Giulio Gavini

INTRODUCTION Bioactive endodontic sealers have been developed to improve the quality of root canal obturation. EndoSequence Bioceramic (BC) Sealer is amongst calcium silicate-based materials recently developed for permanent root canal filling. The objective of this study was to evaluate the bioactivity of BC Sealer and its micro push-out bond strength to dentin compared to AH-Plus (AH) sealer. ...

Journal: :Journal of the American College of Cardiology 2000
S Ueda H Matsuoka H Miyazaki M Usui S Okuda T Imaizumi

OBJECTIVES We sought to test whether tetrahydrobiopterin (BH4) supplementation improves nitric oxide (NO) bioactivity in smokers. BACKGROUND In smokers, endothelium-derived NO bioactivity is impaired. BH4 is an essential cofactor of NO synthase, and its deficiency decreases NO bioactivity. METHODS Sapropterin hydrochloride, an active analogue of BH4 (2 mg/kg body weight), was administered o...

Journal: :Molecules 2008
Bo Li Fei Lu Xinjun Wei Ruixiang Zhao

Fucoidan refers to a type of polysaccharide which contains substantial percentages of L-fucose and sulfate ester groups, mainly derived from brown seaweed. For the past decade fucoidan has been extensively studied due to its numerous interesting biological activities. Recently the search for new drugs has raised interest in fucoidans. In the past few years, several fucoidans' structures have be...

Journal: :International Journal Of Scientific Advances 2020

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