OBJECTIVE Some recent studies have related autoimmune thyroid dysfunction and gestational diabetes (GD). The common factor for both conditions could be the existence of pro-inflammatory homeostasis. The study objective was therefore to assess whether the presence of antithyroid antibodies is related to the occurrence of GD. MATERIAL AND METHODS Fifty-six pregnant women with serum TSH levels ≥...

Comment Evidence of thyroid autoimmunity has often been noted in patients who develop hypothyroidism while receiving amiodarone.2 Between 30% and 50% of patients who have hypothyroidism induced by amiodarone iodine have antithyroid antibodies.' 2 Antithyroid antibodies are less common in patients who have hyperthyroidism induced by amiodarone iodine. Monteiro et al reported the development of a...

Three treatment modalities are available for Graves' disease: antithyroid drugs, surgery and radioactive iodine (RAI). None has been shown to be ideal or superior to the others. There are wide differences between individual physicians and between the physicians in different countries on the optional treatment for childhood hyperthyroidism. While antithyroid drugs remain the initial treatment of...

BACKGROUND AND PURPOSE Patients with hyperthyroidism frequently present with regional cerebral metabolic changes, but the consequences of endocrine-induced brain changes after thyroid function normalization are unclear. We hypothesized that the changes of regional cerebral glucose metabolism are related to thyroid hormone levels in patients with hyperthyroid, and some of these changes can be re...

INTRODUCTION Poorly treated or untreated maternal overt hyperthyroidism may affect pregnancy outcome. Fetal and neonatal hypo- or hyper-thyroidism and neonatal central hypothyroidism may complicate health issues during intrauterine and neonatal periods. AIM To review articles related to appropriate management of hyperthyroidism during pregnancy and lactation. METHODS A literature review was...

Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering with Graves' disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a me...

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...

Purpose Calculation of effective thyroidal half-life (Teff) of iodine-131(131I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients. Methods A total of 256 patients with GD were involved in this study. We investigated the influences of age, gender, disease duration, th...