We report on a 59-year-old man with a 1-year history of forearm erythema, bilateral limb arthralgia, and muscle weakness. During the initial examination we observed infiltrative erythema of the forearm and muscle weakness and atrophy of the limbs. Blood tests revealed marked increases in myogenic enzymes. Because histopathological studies showed lymphocytic infiltration around the small blood v...

The association of thyroid disorders and thyroid-related treatments with psychiatric disorders is well known. What is not recognized yet is if antithyroid antibodies may cause psychosis in the absence of encephalopathy and thyroid dysfunction. I report here the cases of 4 patients who developed de-novo psychosis where I found they had high titers of antithyroid antibodies, both antithyroglobuli...

We report a case of severe hypothyroidism with nongoitrous, autoimmune thyroiditis and pituitary hyperplasia in a 13-year-old boy, who presented with sudden palsy on the left side of his face. Prednisolone and antiviral medication was administered. However, the facial palsy did not improve completely. The medications were replaced with thyroxine, and the facial palsy recovered. Endocrinological...

Sudden sensorineural hearing loss may be present as a symptom in systemic autoimmune diseases or may occur as a primary disorder without another organ involvement (autoimmune inner ear disease). The diagnosis of autoimmune inner ear disease is still predicated on clinical features, and to date specific diagnostic tests are not available. We report a case of bilateral sudden hearing loss, tinnit...

Frequencies of B cell clonal precursors producing antibodies that react with mouse thyroglobulin, mouse erythrocytes, beef hemoglobin, KLH, and sheep erythrocytes were determined by limiting dilution analyses among small, resting lymphocytes, and among large activated cells from normal adult mice. While frequencies of clones reacting with external antigens were equally distributed in large and ...

An indirect, enzyme-linked immunosorbent assay is described for the assay of thyroid autoantibodies, particularly those directed against thyroglobulin. The method is specific, sensitive and precise, and may be automated. The results are shown to correlate well with those obtained by the haemagglutination method.

BACKGROUND AND PURPOSE The possibility that a disorder of immunity might have a role in the mechanism of local inflammatory alterations leading to spontaneous cervical artery dissection (sCAD) has been recently advocated. METHODS We explored this hypothesis in a case-control study, including patients with sCAD (n=29) and patients with non-CAD ischemic stroke (non-CAD; n=29). Serum levels of a...

VOL 58, NO 4 / APRIL 2009 203 www.jfponline.com stimulating hormone (TSH) test to rule out hypothyroidism. The test showed a TSH of 0.2 mIU/L (normal range is 0.35-5.0 mIU/L). Her physician ordered retesting a week later and this time, Mary’s TSH was normal (1.99 mIU/L). The laboratory report also showed elevated free triiodothyronine (T3) of 8.1 pmol/L (normal range 2.6-5.7 pmol/L) and free th...

Two middle aged Caucasian women with no previous history of thyroid or any other disease developed typical subacute thyroiditis (SAT) with minimal thyroidal radioactive iodine uptake. A few months after restoration of euthyroidism and discontinuation of corticosteroid therapy, they developed mild hyperthyroidism due to Graves’ disease (GD), as judged by the increased diffuse thyroidal radioacti...