In recent years, the association between infections and antiphospholipid syndrome has been reported in several epidemiologic and experimental studies that support the idea of infectious induction of aPL [2]. Witmer, et al. [3] reported two children with Mycoplasma pneumoniae pulmonary infection complicated by the development of splenic infarction and transient antiphospholipid antibodies. Among...

Antiphospholipid antibodies are a wide and heterogeneous group of immunoglobulins, whose presence inpatients with arterial and venous thrombosis, and obstetrical complications defines the antiphospholipid syndrome. We systematically reviewed published articles on this syndrome to investigate the association between thrombosis and the most common antiphospholipid antibodies. Lupus anticoagulants...

The antiphospholipid syndrome is a relatively common acquired cause of venous thrombosis. Up to 20% of cases of deep vein thrombosis, with and without pulmonary embolism, may be associated with antiphospholipid antibodies. These antibodies are typically detected in lupus anticoagulant assays and tests for anticardiolipin antibodies. Most antiphospholipid antibodies are directed against several ...

BACKGROUND Cerebral venous sinus thrombosis is a rare and potentially life-threatening neurologic manifestation of antiphospholipid syndrome. Oral contraceptive pills (OCP) may increase the risk of vascular events, even in people without family history of venous thrombosis. CASE PRESENTATION A 31-year-old woman with four weeks of constant headache and history of taking OCP for one year has be...

The mechanism underlying the prothrombotic state that characterizes the primary antiphospholipid syndrome proves to be difficult to define mainly because of the variety of the phospholipid and protein targets of antiphospholipid antibodies that have been described. Much of the debate is related to the use of polyclonal antibodies during the different antiphospholipid assays. To better describe ...

Raised levels of serum antiphospholipid antibodies have most commonly been reported in patients with systemic lupus erythematosus (SLE). There remains, however, a group of patients with raised antiphospholipid antibody levels who do not have any other well defined disease, but do have clinical features associated with these raised antibodies. The clinical, haematological, and serological featur...

Antiphospholipid antibody syndrome (APS) is characterized by the development of venous and/or arterial thrombosis and gestational morbidity (recurrent fetal losses) in presence antiphospholipid antibodies. We report case a 38-year-old woman who was diagnosed with primary APS from thromboembolic abnormalities retinal periphery that led to ischemia. The aim this study share physicians medical und...

Antiphospholipid syndrome is probably the most common acquired hypercoagulable state, but information on perioperative management is sparse. Minor alterations in anticoagulant therapy, infection, or a surgical insult may trigger widespread thrombosis. The perioperative course of a 31-yr-old woman with primary anticardiolipin antiphospholipid antibody syndrome requiring a mitral valve replacemen...