The aim of this study was to establish why oxidative type muscles (soleus muscle, SM) are resistant to muscle cachexia induced by dexamethasone disodium phosphate overload (2 mg/kg b.w. day during 5 consecutive days). DEX treatment was associated with the dramatic drop in total antioxidant status, that was partially corrected by the supplementation with antioxidants. The relationships between t...

Red blood cells (RBC) possess strong antioxidant activity. We tested whether this activity was sufficient to prevent the oxidative inactivation of alpha 1-antitrypsin (alpha 1-AT) by cigarette smoke. We found that RBC in physiological concentrations completely prevented the inactivation of alpha 1-AT. The major erythrocytic antioxidants, catalase, superoxide dismutase and glutathione were then ...

OBJECTIVE To investigate if blood Cu++/Zn++ superoxide dismutase, glutathione peroxidase, catalase, and total plasma antioxidant activities could be markers of biological activity resulting from exposure to respirable coal mine dust in active miners, and of pneumoconiosis in retired miners. METHODS Blood samples were randomly obtained from active surface workers (n = 30) and underground miner...

One of the ways to prevent generative diseases is by using natural antioxidant compounds. The flavonoid compounds in flower parts M. gigantea have a role antioxidants. Thus study aimed test activity and levels flowers. was carried out UV-vis spectrophotometry 2,2-diphenyl-1-picrylhydrazyl assay 10% aluminum chloride potassium acetate, both tests quercetin as comparison. results this obtained IC...

Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDsantioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid sp...

BACKGROUND The increasing consumption of fruits and vegetables has contributed to the improvement of populational health, due in part, to the abundance of antioxidants in these foods. Antioxidants reduce the level of oxidative damage to DNA caused by free radicals and ionizing radiation, including the radioisotope iodine-131 (131I). This isotope is used for the diagnosis and treatment of thyroi...

Exercise has been shown to increase the production of reactive oxygen species to a point that can exceed antioxidant defenses to cause oxidative stress. Dietary intake of antioxidants, physical activity levels, various antioxidants and oxidative stress markers were examined in 20 exercise-trained "athletes" and 20 age- and sex-matched sedentary "controls." Plasma F2-isoprostanes, antioxidant en...

Germination is one of the most effective processes to improve the quality of legumes. Vitamins and some other compounds that might be considered beneficial as antioxidants, often change dramatically during the course of germination. Antioxidants might be defined as compounds which are capable of preventing, delaying or retarding the development of rancidity or other flavor deterioration in food...

Various side effects of synthetic drugs, has necessitated the move to more natural antioxidants. The demand for highly effective antioxidants having low or no side effects for use in preventive medicine and the food industry is increasing. As plants produce significant amount of secondary methabolites, mostly antioxidant compounds, they are almost replacing the synthetic antioxidants. Plant ant...

Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of cytokine-induced beta-cell destruction in type 1 diabetes. We produced transgenic mice with increased beta-cell expression of manganese superoxide dismutase (MnSOD) and catalase. Expression of these antioxidants increased beta-cell ROS scavenging and improved beta-cell survival after treatment with different sources o...