several studies reported the appearance of asthma and autoimmune conditions in the same patient, but the clinical significance of this association was not yet assessed. one hundred asthmatic patients were observed for one year evolution with death, severe exacerbations, intake of > 1000 micrograms of beclometasone or equivalent (high ics) and fev1 decline >100 ml, in relation with ana (elisa), ...

Granulocyte-specific antinuclear antibodies (GS-ANA) were detected in the sera of 5 of 88 patients with ankylosing spondylitis (AS) and in 7 of 52 cases of psoriatic arthritis (PsA), but were not found in 91 patients with malignant or non-malignant chest disease nor in 25 cases of psoriasis. Organ non-specific ANA were present in serum from 6 cases of AS and 1 of PsA. None of the sera gave sign...

Two immunofluorescence procedures to evaluate antinuclear antibodies were compared in a series of 221 patients with chronic liver disorders of various aetiologies. The use of HEp-2 cells allowed us to discriminate with more confidence between the homogeneous and speckled patterns, to show the presence of associated patterns in the same serum, and, above all, to identify two specificities, unrec...

OBJECTIVE To investigate patients with cancer for the frequency of IgG and IgM aCL and ANA in comparison to a group of age- and sex-matched controls. METHODS Serum levels of IgG and IgM anticardiolipin antibodies (aCL), antinuclear antibodies (ANA) and anticytoplasmic antibodies were evaluated in 145 cancer patients, including 20 patients with thromboembolic disease (TED) and compared with ag...

Xiana Rodrı́guez-Osorio *, Javier López-González , Ana López-Ferreiro , José Marı́a Domı́nguez-Lorenzo , Manuel Peleteiro-Fernández b Department of Neurology, Hospital Clı́nico Universitario de Santiago de Compostela, Travesa da Choupana s/n, CP 15706, Santiago de Compostela, Spain Department of Neurophysiology, Hospital Clı́nico Universitario de Santiago de Compostela, Travesa da Choupana s/n, CP 1...

Sera from 21 patients with arteritis of the aorta and great vessels were studied. The mean level of IgG, IgM, and IgA immunoglobulin was raised. The incidence of rheumatoid and antinuclear factor and antibodies to aorta, liver, and thyroid was not raised.