objective(s): the aim of study was to investigate the antinociceptive effect of intracerebroventricular (icv) microinjection of origanum vulgare (org) extract and possible involvement of opioid receptors.   materials and methods: cannula was inserted into left ventricle of male rats. five days after surgery tail flick latency (tfl) was measured after icv microinjection of, org (1, 3 and 6 μg / ...

The methanolic extract of Clerodendrum viscosum Vent. (Verbenaceae) was evaluated for in vitro antioxidant activity by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in swiss albino mice. The results revealed the presence of pronounced antioxidant property as ...

The methanol extract of Mimosa pudica was studied for its antibacterial activity against twelve pathogenic bacteria. also effect on acetic acid induced writhing model in mice. showed good two gram-positive and six gram-negative bacteria but failed to show any Staphylococcus pyogenes, Salmonella typhi, Shigella boydii Vibrio cholera. exhibited no antinociceptive test; rather it increased the abd...

croton guatemalensis lotsy (cgl), known as “copalchi” in chiapas, mexico, is used for the treatment of fever, abdominal pain and malaria and also as a remedy for chills and for treating rheumatism. the aim of this study was to evaluate whether aqueous extracts from the bark of this plant possesses indeed antinociceptive properties by using two different animal models of nociception, the acetic ...

The plants of the genus Polygala (Polygalaceae) are employed in folk medicine for the treatment of several pathologies, including disorders of the bowel and kidney, as anesthetic, expectorant and anti-inflammatory. The present study was undertaken to investigate the antiedematogenic and antinociceptive activities of methanolic extract of Polygala boliviensis A. W. Benn (MEPB) in mice. The antin...

Objective: Berberis vulgaris has antioxidant, hepato--renal protective, antibacterial, lipid lowering, anti-inflammatory and antinociceptive activities. The genus Berberis, has another member called Berberisintegerrima which has not been studied for antinociceptive activity and therefore, this study was aimed to examine the antinociceptive effect oftotal extract and alkaloid fractions of Berber...

The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a ...

Exposure of mice to the anesthetic gas N2O evokes a prominent antinociceptive effect that is sensitive to antagonism by nonselective nitric-oxide synthase (NOS) inhibitors. The present study was conducted to identify whether a specific NOS isoform is implicated in N2O antinociception in mice. In the abdominal constriction test, exposure of mice to 25, 50, and 70% N2O resulted in a concentration...