the human Mantoux.3 If skin testing is equivocal, or in cases of infection involving potentially vulnerable sites (such as the mastoid), when adjuvant antimycobacterial drug treatment is given, then it may be helpful to have the surgical specimen examined by the polymerase chain reaction.4 This allows differentiation between M tuberculosis and NTM infection, although the specificity and sensiti...

The prevalence of mycobacterial infection has increased in recent years, especially in patients immunocompromised due to autoimmune disease, malignancy and AIDS. Mycobacterium kansasii infection most commonly presents as tuberculosis-like pulmonary disease. We report the case of a 38-year-old woman with systemic lupus erythematosus (SLE) who developed cellulitis over the left lower leg and had ...

Spondiasmombin is a widely cultivated edible plant used in folkloric medicine for the treatment of severe cough and other respiratory disorders. This study evaluated the anti tubercular property of the stem of S. mombin against Mycobacterium tuberculosis (H37Rv and EJA-2011) using agar proportion assay on Lowenstein-Jensen medium. Four new compounds were isolated from the stem of Spondiasmombin...

It is an acceptable medical practice to use second-line antimycobacterial drugs in combination with isoniazid in treatment of isoniazid-resistant tuberculosis. Recent investigations have demonstrated the importance of determining chemotherapeutic interaction in instances of multiple antibiotic use. We studied the inhibitory effect of combinations of isoniazid with ethambutol, rifampin, ethionam...

The present study reveals that the effect of extra cellular protein isolated from Psychrophilic Actinomcetes against clinical pathogens. Totally 13 Actinomycetes were isolated from glacier soil. Among them the genus Streptomycetes and Micromonospora were isolated highly. MM9 medium was used as fermentation medium and the antimicrobial peptide activity was performed by disc diffusion method. Out...

A prospective multicentre open study has been conducted in France in order to assess the efficacy and tolerability of an antimycobacterial regimen including rifabutin in the treatment of patients with pulmonary tuberculosis due to rifampicin and isoniazid resistant bacilli. Patients were treated with daily rifabutin (450-600 mg), associated with companion drugs to which the organisms remained s...

A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, ¹H-NMR and ¹³C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. In general, the minimum inhibitory concentrations range from 1 to 500 µmol/L. Th...

This paper describes the synthesis and application of alginate-chitosan-cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds. Preparation and morphology of the obtained particles, as well as antimycobacterial activity data of the obtained systems are presented. Docking of isoconazole into the active site of enoy...

The resurgence of tuberculosis has caused considerable effort to be focused on the development of rapid methods for determining the susceptibility of Mycobacterium tuberculosis to antimycobacterial agents. We demonstrated that susceptibility testing of M. tuberculosis can be accomplished rapidly by using flow cytometry. Results of tests were available within 24 h after M. tuberculosis organisms...

The aim of present study is to synthesize a series of different p-substituted benzyl thiosemicarbazone and evaluate their cytotoxicity as well as their antimycobacterial activity. The chemical structures have been assigned by micro analysis and spectral data (UV-Vis, IR and H NMR). All the compounds have been tested for their in vitro cytotoxic activity against leukaemia cancer cell line K562 a...