نتایج جستجو برای: antifungal drugs
تعداد نتایج: 245633 فیلتر نتایج به سال:
Ketoconazole (KTZ) and other azole antifungal agents are known to have a variety of actions beyond the inhibition of sterol synthesis in fungi. These drugs share structural features with a series of novel heme oxygenase (HO) inhibitors designed in our laboratory. Accordingly, we hypothesized that therapeutically used azole-based antifungal drugs are effective HO inhibitors. Using gas chromatogr...
Background: Vaginal candidiasis is a common cause of vaginal infections. Currently, for treatment of these infections, fluconazole is prescribed more than other drugs; so determining the drug resistance of Candida to fluconazole and comparing it with itraconazole as a substitute has been one of the main objectives of this study. Materials and methods: Of 180 patients with symptoms of vaginal c...
background: antifungal drug resistance and few numbers of available drugs limit therapeutic options against fungal infections. the present study was designed to discover new antifungal drugs. m aterials and methods: this study was carried out in two separate steps, that is, in silico lead identification and in vitro assaying of antifungal potential. a structural data file of a ternary complex...
We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs. To establish an experimental, in vivo model of onychomycosis, we applied Trichophyton mentagrophytes TIMM2789 to the nails of the hind limbs of rabbits that underwent steroid treatment. The nails were taken from the...
Fungi are eukaryotic organisms that potentially have the ability to cause disease in humans and animals. Fungal infections are called mycosis, which are divided into four types of superficial, cutaneous, subcutaneous and systemic, depending on the area of the body involved. Though cutaneous mycoses are rarely life-threatening infections, they can isolate the patient socially due to the disfig...
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