Schiller Y, Bankirer Y. Cellular mechanisms underlying antiepileptic effects of lowand high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro. J Neurophysiol 97: 1887–1902, 2007. First published December 6, 2006; doi:10.1152/jn.00514.2006. Approximately 30% of epilepsy patients suffer from drug-resistant epilepsy. Direct electrical stimulation of the epilep...

Increasingly, the epilepsy nurse specialist has become an integral part of the specialist epilepsy team. Nurse specialists, who practice at an advanced level, frequently advise patients on diagnosis and antiepileptic drug changes. The inclusion of antiepileptic drugs to the nurse Prescribing Formulary would allow specialist nurses to provide a more enhanced service to patients.

R a c b e C t s w ‘ o ( P The lead article in this issue by Bialer and colleagues is a summary of the Eleventh Eilat Conference on New Antiepileptic Drugs and once again provides a comprehensive progress report on new antiepileptic drugs. This is the 10th such progress report from the Eilat conferences to appear in the pages of Epilepsy Research since 1995. The summary in this issue focuses onl...

background: besides the well-known adverse effects of valproate (vpa), disorders related to male reproductive functions have been reported. furthermore, only a limited number of previous studies have reported the relationship between vpa dose and impairment of the hormonal axis and semen quality. a patient with reversible changes that occurred in the sperm parameters after a dose increment of v...

Antiepileptic drug combination therapy remains an empirical second-line treatment approach in trigeminal neuralgia, after treatment with one antiepileptic drug or other nonantiepileptic drugs have failed. The results in three patients followed in our clinic are not sufficient to draw definitive conclusions, but suggest the possibility of developing this type of therapeutic approach further.