BACKGROUND Antidepressant prescribing is increasing worldwide, prompting policy interventions and targets to halt the rise. AIM To examine time trends in GP antidepressant prescribing using patient-level data. DESIGN AND SETTING Longitudinal population database of all community pharmacy dispensed prescriptions for all 325,000 residents of the Tayside region of Scotland. METHOD In each of ...

BACKGROUND Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depression scores. The purpose of this analysis is to establish the relation of base...

With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-ben...