Previous experiments (l-3) have shown that following hypophysectomy the serum globulin concentration of dogs and rats increases and at the same time the serum albumin level falls. In the above studies serum albumins and globulins were separated by salt fractionation (4). With the aim of checking our earlier results and of obtaining more detailed information regarding the changes in serum protei...

BACKGROUND A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. DESIGN AND METHODS Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compare...

BACKGROUND Currently, there is no effective intervention for a primary cytomegalovirus (CMV) infection during pregnancy. METHODS We studied pregnant women with a primary CMV infection. The therapy group comprised women whose amniotic fluid contained either CMV or CMV DNA and who were offered intravenous CMV hyperimmune globulin at a dose of 200 U per kilogram of maternal weight. A prevention ...

BACKGROUND Previous studies have confirmed that serum concentrations of actin-free Gc globulin (Af-Gc globulin) may provide prognostic information in patients withacute liver failure (ALF). However, until now the relation between plasma Af-Gc globulin levels and chronic or acute-on-chronic liver failure (CLF or ACLF) caused by HBV is unknown. METHODS Plasma Af-Gc globulin in 56 patients with ...

polyclonal anti-thymocyte globulin (atg) is used as an immunosuppressive agent in the treatment of aplastic anemia (aa). serum sickness is a recognized side effect of atg. we observed abnormal skin manifestation in patient with aplastic anemia who had been treated with atg. we conclude that abnormal immune function caused by aplastic anemia and atg and corticosteroids may aggravate the signs of...

OBJECTIVE To determine dynamic Gc-globulin level change in Acute-on-Chronic Hepatitis B Liver Failure (ACHBLF) patients, and evaluate the prognostic value of Gc-globulin. STUDY DESIGN An analytical study. PLACE AND DURATION OF STUDY The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, from January 2010 to December 2012. METHODOLOGY A total of 54 consec...

The problem as to whether or not the globulin fractions obtained from blood serum are chemical entities has been the subject of much discussion recently. Svedberg (l), basing his views on particle (molecular) weight determination, came to the conclusion that there is only one serum globulin, the molecular weight of which he determined to be 103,800. Sorensen (2) concluded, however, from solubil...

The effect of potent sheep anti-mouse interferon globulin was investigated in several different experimental virus diseases of mice. In anti-interferon globulin-treated mice infected intraperitoneally with herpes simplex virus (HSV) type I, the latent period was shortened, and the overall LD50 was increased several hundredfold compared to virus-infected control mice. When HSV was inoculated sub...