A patient developed bleeding due to an acute acquired specific prothrombin deficiency. Unlike previously described patients, this patient had no evidence of an associated lupus anticoagulant. Prothrombin activity and antigen were decreased concordantly and the patient's plasma did not neutralize the activity of added prothrombin or interfere with its measurement by electroimmunoassay. Neverthel...

Children with frequent recurrent episodes of otitis media may have a deficient IgG2 antibody response to polysaccharide antigens. Five otitis-prone children were vaccinated with heptavalent pneumococcal conjugate vaccine. While all had an IgG1 antibody response to all pneumococcal serotypes included in the conjugate vaccine, the IgG2 response, especially to serotypes 6B, 9V, 19F, and 23F, was p...

introduction : hepatitis a virus is the most prevalent viral hepatitis. it is globally a major public health problem with different clinical symptoms. this study aimed at investigating the clinical findings and prevalence of glucose 6-phosphate dehydrogenase (g6pd) deficiency in children with hepatitis a. materials and methods : in this prospective study, demographical information, clinical fin...

Objective: Vitamin D deficiency is associated with high susceptibility to infections. The present study aimed at exploring the relationship between vitamin levels and Toxoplasma gondii ( T. ) infection, on basis of a nationally representative database. Methods: data came from National Health Nutrition Examination Surveys (NHANES) 2001–2004. Participants underwent both IgG antibody testing serum...

PURPOSE Use of the T cell-dependent neoantigen bacteriophage ΦX 174 has been described since the 1960s as a method to assess specific antibody response in patients with primary immunodeficiencies. We reviewed a cohort of patients at Duke University Medical Center who received immunization with bacteriophage and report the clinical utility and safety of the immunization, as well as patient chara...

Treatment approaches for advanced ovarian cancer should consider several factors. Among the most important are platinum sensitivity, status of BRCA and homologous recombination deficiency (HRD), changing indications PARP inhibitors in recurrent disease maintenance. have demonstrated clear benefit patients with mutated tumors, especially first-line setting, HRD testing can guide their use withou...

Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding the diagnosis and treatment of SAD, and its clinical significance is not well u...

The effect of vitamin A deficiency on the immune response to epizootic diarrhoea of infant mice (EDIM) rotavirus was studied in mice. The virus was given by oral dosing or by intraperitoneal injection. For oral challenge, weanling mice were fed on either a control or vitamin A-deficient diet ad lib. or pair-fed the control diet to the intake of the vitamin A-deficient group. A fourth group was ...

BACKGROUND Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. OBJECTIVE To investigate correlation between tTg levels and histological alterations and ...