OBJECTIVES To study the changes in the pharmacokinetics and tissue distribution of the aminoglycoside amikacin in rats using amikacin carrier erythrocytes as a delivery system. METHODS Amikacin-loaded erythrocytes were obtained using a hypotonic dialysis method. The pharmacokinetic and tissue distribution of amikacin were studied in three groups of rats receiving intravenous amikacin in salin...

Antibiotics such as β-lactams and aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity, resulting in low effectiveness against intracellular pathogens and the emergence of antibiotic resistance. Here we reported that an endogenous aminoglycan, hyaluronic acid could be an effective carbohydrate carrier of the aminoglycoside antibiotic, streptomyci...

Iatrogenic traumatic endophthalmitis is a rare but serious ocular infection that can lead to severe vision loss. A 44-year-old man presented with pain and decreased vision in the right eye 4 hours after injury with a hypodermic needle during irrigation of his eye. Slit-lamp examination revealed a penetrating corneal puncture and iris hole in the right eye. Twenty hours later, his visual acuity ...

Psoriasis is an inflammatory skin disease affecting ∼2% of the world's population, but the aetiology remains incompletely understood. Recently, microbiota have been shown to differentially regulate the development of autoimmune diseases, but their influence on psoriasis is incompletely understood. We show here that adult mice treated with antibiotics that target Gram-negative and Gram-positive ...

Pituitary abscess is a rare but critical disorder caused by an infectious process where purulent material accumulates inside the sella turcica. Since symptoms, signs and radiographic characteristics of pituitary abscess are similar to several other pituitary lesions, correct diagnosis before surgery is challenging. In this article, two cases of pituitary abscess treated in our department are re...

Hsldw S.A.1, Buh~r~~nly J.1, Haswll P.D.1, Bowbr I.C.J.W.2, Bmn A.J.1 1 Depatlmenl of Ophthalmology, University ot Oxford. 2 Department of Bacterioboy. Oxford Regional FMii Heaith Laboratory. Purpose: lntravitreal antibiotic is the mainstay of endophthalmitis treatment. Repeat injections should be based on the knowledege of tissue levels. The purpose of this study is to assess the value of aque...

Hsldw S.A.1, Buh~r~~nly J.1, Haswll P.D.1, Bowbr I.C.J.W.2, Bmn A.J.1 1 Depatlmenl of Ophthalmology, University ot Oxford. 2 Department of Bacterioboy. Oxford Regional FMii Heaith Laboratory. Purpose: lntravitreal antibiotic is the mainstay of endophthalmitis treatment. Repeat injections should be based on the knowledege of tissue levels. The purpose of this study is to assess the value of aque...

THREE decades ago in the pre-antibiotic era, infection of a major joint carried an appreciable mortality and the end result of the joint was usually disastrous. Treatment consisted of rest and drainage, either by aspiration or formal surgical exploration. Since the introduction of antibiotics the results have improved dramatically. At first antibiotics were given systemically then later supplem...

We describe an unusual case with a modified treatment approach in interdisciplinary setting, of pregnant woman pyogenic pontine abscess. After acute cesarean section, contrast-enhanced MRI confirmed the finding severe The patient was treated antibiotics, glucocorticosteroids, and stereotactic evacuation. She improved during eight weeks antibiotics steroids, post-operative showed reduction absce...

Examination of blood and organ concentrations of sporamycin in normal mice showed a rapid decrease of sporamycin from peripheral blood and a high level of sporamycin in urine 10 minutes after intravenous injection of the antibiotic. At the same time, the highest level was found in the kidneys and low levels were found in the lungs and spleen. When sporamycin was added to mouse organ homogenate ...