Heterocyclic compounds containing a pyrimidine nucleus are of special interests due to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivati...

A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.

Background: Pistacia khinjuk is one of the three species Pistacia growing in Iran. The essential oils of some Pistacia plants contain variety of components with different therapeutical effects. Objective: The purpose of this study was to provide the examination of antibacterial and antifungal effects of chloroform, ethyl acetate, ethyl alcohol and diethyl ether extracts obtained from the leaves...

PURPOSE This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties. METHODS The novel compounds synthesized were characterized by elemental analysis, IR and (1)HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method. RESULTS The compound p-t showed more antib...

Despite the available data regarding antimicrobial activity of phenolic acids, studies dealing with the effects of their metabolites or derivatives are scarce. Therefore, the antimicrobial and demelanizing activities of Coprinopsis atramentaria extract, its organic acids, and methylated and glucuronated derivatives were evaluated. The antifungal activity was stronger than the antibacterial effe...

New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form (THCZ), where latter is reacted NSAID (Ketoprofen) via amide bond yield
 THCZ, compounds chemical structures verified by: 1H, 13C NMR and FTIR spectroscopy.
 Antifungal activit...

BACKGROUND Premna resinosa (Hochst.) Schauer also called "mukarakara" in Mbeere community of Kenya is used in the management of respiratory illness. In this study we investigated antituberculous, antifungal, antibacterial activities including cytotoxicity and phytochemical constituents of this plant. METHODS Antibacterial and antifungal activities were investigated by disc diffusion and micro...

the series of 3-(substitutedphenyl)-n-(4h-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-triazole with acetyl chloride followed by claisen-schmidt condensation reactionwith different aromatic aldehydes. the structures of new compounds were confirmed by ir, 1h-nmr and13c-nmr spectral data. anti-bacterial and anti-fungal activities were evaluated and compared wi...

Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study described the antibacterial and antifungal activities of pomegranate peel extract (rind), seed extract, juice and whole fruit on the selected bacteria and fungi. The peel extract has shown highest antimicrobial activity compared to other extracts. Amo...

Paenibacillus polymyxa strain YC0136 is a plant growth-promoting rhizobacterium with antimicrobial activity, which was isolated from tobacco rhizosphere. Here, we report the complete genome sequence of P. polymyxa YC0136. Several genes with antifungal and antibacterial activity were discovered.