Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101), and is clinically used in combination therapy for gastrointestinal cancer and small cell lung carcinoma. PSK is a biological response modifier (BRM), and its mechanism of action is partly mediated, by modulating host immune systems, such as the activation of immune effector cells and the neutralization of transf...

Background: Carnosine is a dipeptide molecule (?-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It used in exercise physiology as food supplement to increase performance; however, vitro evidence suggests that carnosine may exhibit anti-cancer Methods: In this study, we investigated the effect of on breast, ovarian, colon, leukemic cancer cell ...

A variety of vegetable and fruit derived food oils are considered beneficial for human health due to their content functional components including positive effects in cardiovascular system. In addition the favorable ratio unsaturated versus saturated fatty acids, some these include also other compounds such as vitamins, minerals, pigments, enzymes phenolic compounds. Particularly polyphenols ha...

Aplog-1 is a simplified analog of the tumor-promoting aplysiatoxin with anti-proliferative and cytotoxic activities against several cancer cell lines. Our recent findings have suggested that protein kinase Cδ (PKCδ) could be one of the target proteins of aplog-1. In this study, we synthesized amide-aplog-1 (3), in which the C-1 ester group was replaced with an amide group, to improve chemical s...

The current global shortage of organ resources, the imbalance in donor-recipient demand and increasing number high-risk donors make preservation a necessity to consider appropriate storage options. method use often has risks such as blood group mismatch, short shelf life, susceptibility. HBOCs have positive effects anti-apoptotic, anti-inflammatory, antioxidant anti-proliferative, which signifi...

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis. While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers anti-proliferative and pro-apoptotic responses while enhancing anti-tumor immunity. Despite being activated downstream of common cytokine and growth factor receptors, thei...

objective(s): artemisia is a genus of herbs and small shrubs forms an important part of natural vegetation in iran. it has been reported that several artemisia species possess anti-proliferative effects. considering the value of this genus in anti-cancer researches we have chosen artemisia biennis for cytotoxic and mechanistic studies. materials and methods:in this study we have investigated th...

Dimethylaminoparthenolide (DMAPT), a water-soluble analogue of natural product parthenolide, possesses anti-inflammatory and anti-tumor activities. Despite that the anti-inflammatory mechanism of DMAPT has been well studied, specific target(s) for DMPAT and its anti-tumor mechanism remain poorly understood. In this study, to assess the anti-proliferative effects of DMAPT in pancreatic cancer ce...

Abstract Background Naturally occurring substances of plant origin have long been used in folk medicine for curing various ailments including fever, pain, and inflammation etc. After careful evaluation on scientific bases, a large number those provides cheaper alternative to currently synthetic or semi-synthetic agents. Thus, with an aim discovering treatment such ailments, current study was ca...