Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successf...

Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10...

Bovine tuberculosis (TBB) is a zoonotic disease distributed worldwide and is of great importance for public health and the livestock industry. Several experimental vaccines against this disease have been evaluated in recent years, yielding varying results. An example is the Bacillus Calmette-Guérin (BCG) vaccine, which has been used extensively in humans and tested in cattle showing mixed resul...

background: mycobacterium bovine, as the etiology of bovine tb, involves human in some cases and with mycobacterium tuberculosis are regarded as global health problems. the aim of this study was to extract and compare protein profile of these strains in order to achieve effective biomarkers for diagnosis and the vaccine components. materials and methods: first, the clinical samples were culture...

Using aroyl hydrazides as a source of amine and substituted aromatic aldehydes as a carbonyl source, we have synthesized aroyl hydrazide derivatives by condensation reaction. The synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. The Synthesized compounds were subjected to antimicrobial and anti-oxidant activities. Finally, molecular docking study had been p...

A 68-year-old man on peritoneal dialysis (PD) was hospitalized with the clinical picture of peritonitis. The patient was diagnosed with peritonitis caused by nontuberculous mycobacteria (NTM) according to positive Ziehl-Neelsen staining and negative Mycobacterium tuberculosis polymerase chain reaction results. Oral levofloxacin and clarithromycin, and later intraperitoneal imipenem were started...

BACKGROUND The present study was aimed to evaluate whether IgG, IgM and IgA antibodies levels detected against a novel Mycobacterium tuberculosis polyprotein 38 F-64 F (with 38 F being the abbreviation for 38kD-ESAT6-CFP10 and 64 F for Mtb8.4-MPT64-TB16.3-Mtb8) are suitable for diagnosing active tuberculosis, and for monitoring the efficacy of chemotherapy on TB patients. METHODS In this stud...

The tuberculosis is a typically chronic infection caused by Mycobacterium tuberculosis. The progress of effective treatment of tuberculosis (TB) has been recently due to alarm regarding the appearance of vastly drug-resistant TB strains. The efforts that gave rise to current first line and second-line anti-TB drugs in global use today and attempts to summarize ongoing discovery being conducted....

Nontuberculous mycobacteria are common microorganisms in nature and are particularly found in soil and water. They cause pulmonary infections, lymphadenitis, disseminated infections, localized skin and soft tissue infections, tendon–bone–articular infections, and catheter infections. Mycobacterium xenopi is categorized as a slow-growing mycobacterium. Pulmonary infections caused by M. xenopi ha...

Endobronchial tuberculosis (EBTB) is defined as (TB)infection of the tracheobronchial tract. Tracheal and bronchial involvement from TB infection was first reported by Morten in 1698. a form that difficult to diagnose because lesions are frequently undetectable sputum examination chest X-ray alone. present 10-40% active patients more than 90% cases accompanied stenosis various degrees. The main...