OBJECTIVE The objective of this study was to analyze the potential risks involved in the administration process of intravenous anti-infective medication at a medical clinic, using the Failure Mode and Effect Analysis. METHOD This exploratory study was conducted at the medical clinic of a hospital in the State of Goiás. For data collection we convened a team comprised of six professionals invo...

The structure of the title sulfonamide, C(12)H(15)Cl(2)NO(2)S, features a distorted tetra-hedral geometry for the S atom [maximum deviation: O-S-O = 120.23 (14)°]. One of the sulfonamide O atoms is coplanar with the benzene ring [C-C-S-O torsion angle = -174.5 (2)°], whereas the other lies well above the plane [C-C-S-O = 57.0 (3)°]. A chair conformation is found for the cyclo-hexyl ring. In the...

Antiseptics and disinfectants are extensively used in hospitals and other health care settings for a variety of topical and hard-surface applications. A wide variety of active chemical agents (biocides) are found in these products, many of which have been used for hundreds of years, including alcohols, phenols, iodine, and chlorine. Most of these active agents demonstrate broad-spectrum antimic...

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue Markus Müller, Amparo dela Peña, and Hartmut Derendorf* Health Science Center, Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, and Vienna General Hospital, Division of Clinical Pharmacokinetics, Department of Clinical Pharmacology, School of Medicine, V...

We describe a rapid, precise, and reliable procedure for assay of trimethoprim in serum and urine by ion-pair chromatography. Trimethoprim concentrations in urine are determined by an externally standardized, direct-injection procedure; assay in serum involves a simple preliminary extraction and internal standardization. The assays are suitable for pharmacokinetic studies and have been applied ...

To the Editor, " Indian Medical Gazette." Sib,?Writing last month a surgeon?Mr. Tertius Clarke disputes the power of carbolic acid in Surg.-Lt.-Col. Quill's " antiseptic" prescription for enteric fever. He believes that l'5'5% in 36 cases in India" (I presume among young soldiers), "is better than the 4% of Dr. Barr, Liverpool," and yet he is " not inclined to accept Dr. Quill's conclusions as ...

The purpose of this study was to investigate the occurrence of antibiotic resistance genes (ARGs) in water used for irrigation in the Werribee River Basin, Australia, including river water and reclaimed effluent water (reclaimed water). Samples of reclaimed water, collected over a one-year period, were screened for the occurrence of ARGs using PCR detection assays. The presence of ARGs in the r...

Infection control personnel familiar with the studies underlying recent guideline recommendations for the prevention of intravascular catheter-related infections could conclude that it would be easy to minimize the risk of such infections. Randomized, controlled trials have demonstrated that prepping the skin with chlorhexidine antiseptic can reduce the risk of catheter-related bloodstream infe...

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...

The purpose of the study is to give the rising incidence of Salmonellosis and the continuous decrease of sensitivity of Salmonella to a range of antibiotics, the prime importance of the choice of optimal anti-infective chemotherapy in order to prevent the selection of multidrug-resistant strains (MDR). We have studied 54 strains of Salmonella sent for further investigation to "Cantacuzino" NIRD...