Human Immunodeficiency Virus (HIV-1) poses a serious threat to the developing world and sexual transmission continues to be the major source of new infections. Therefore, the development of molecules, which prevent new HIV-1 infections, is highly warranted. In the present study, a panel of human hemoglobin (Hb)-α subunit derived peptides and their analogues, with an ability to bind gp120, were ...

Predictive quantitative structure–activity relationship was performed on the novel 4-oxo-1,4-dihydroquinoline and 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives to explore relationship between the structure of synthesized compounds and their anti-HIV-1 activities. In this way, the suitable set of the molecular descriptors was calculated and the important descriptors using the variable selections ...

Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory ...

Problem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypo...

Viral load testing is the gold standard for HIV treatment monitoring, periodic viral tests are most accurate way of determining whether antiretroviral working to suppress replication HIV. The achievement suppression among persons living with has a lot benefits individual, community, and entire population level. Therefore, review aimed at summarizing documenting public health impact monitoring P...

Anti-TNF-alpha is now established as a major player in the treatment of Crohn's disease, however the use of anti-TNF-alpha therapy in patients concomitantly having HIV infection and Crohn's disease is a relatively unexplored subject. There is generally some apprehension and anxiety to use infliximab in patients with HIV. One case has been reported in literature of usage of anti-TNF-alpha in HIV...

BACKGROUND/AIMS To assess the durability of protective hepatitis B surface antibody (anti-HBs) titers in HIV-infected patients who responded to double-dose hepatitis B virus (HBV) rescue vaccination. METHODS A retrospective chart review was performed for HIV-infected patients who received the double-dose HBV rescue vaccination at 0-, 1-, and 2-month intervals after they had failed conventiona...

Viral load testing is the gold standard for HIV treatment monitoring, periodic viral tests are most accurate way of determining whether antiretroviral working to suppress replication HIV. The achievement suppression among persons living with has a lot benefits individual, community, and entire population level. Therefore, review aimed at summarizing documenting public health impact monitoring P...

Antigangliosides antibodies were observed in neoplastic diseases, bacterial and viral infections, autoimmune diseases and neurological disorders. Objective: assessment of antigangliosides antibodies anti -GM1, -GM2, -GM3, -GD1a, -GD1b, -GT1b, -GQ1b of IgG type in asymptomatic HIV patients. The study was based on the prospective analysis of 32 patients with asymptomatic HIV infection, with no re...