Background Colon cancer continues to be the third most commonly occurring around globe with both lifestyle-related risk factors and genetic dispositions. Owing increased incidence of disease, there is a need find new treatment options which are easily accessible less toxic cells. Cynaropicrin, sesquiterpene extract from artichoke plant exhibits varied properties such as anti-inflammatory, anti-...

objective: silybin is a polyphenol with anti-oxidant and anti-cancer properties. the poor bioavailability of some polyphenols can be improved by binding to phosphatidylcholine. in recent years, studies have been conducted to evaluate the anti-cancer effect of silybin. we studied the effect of silybin and silybin-phosphatidylcholine on esr1 and esr2 gene expression and viability in the t47d brea...

Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...

Background and objective: Helicobacter pylori infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This bacterium is the cause of many diseases such as lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, H. pylori infection can potentially increase the risk of colon cancer. The cu...

Objective: Opuntia humifusa (O. humifusa) Raf. has been used for the prevention and treatment of rheumatoid arthritis, inflammation, and cancer. Our study was designed to unveil the anti-nociceptive and anti-inflammatory effects of the methanolic extract of O. humifusa Raf stem (OHS).  Material and Methods: The anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and...

Cancer is one of the leading causes death worldwide, with a mortality rate more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance still major problem especially metastatic disease. Targeted increasingly used conventional to patients’ outcomes advanced and tumors. However, due complexity cancer biology metastasis, i...

Quinones such as 1,4-naphthoquinones are abundant in nature and naphthoquinone based natural products are known to possess anticancer activity. This pharmacophore is known to convey anticancer activity to some drugs such as streptonigrin, mitomycin A, etc. We synthesized and characterized different classes of naphthoquinone derivatives including bis naphthoquinone, 2-arylaminonaphthoquinone, be...

Chemical immunotherapeutic strategies including Antibody Recruiting Molecules (ARMs - bivalent small molecules containing an antibody-binding domain (ABD) and a target-binding (TBD)) direct immune-mediated clearance of diseased cells. Anti-cancer ARM function relies on high tumor antigen valency, limiting against lower expressing tumors. To address this limitation, we report tunable multivalent...

the polyphenol silybin has anti-oxidant and anti-cancer properties. the poor bioavailability of some polyphenols (flavonoids, and terpenoids) can be improved by binding them to phosphatidylcholine (phytosome technology). many studies have focused on the most common phytosome, silybin-phosphatidylcholine, particularly for its hepatoprotective effects. however, in recent years, studies have also ...