BackgroundThe androgen receptor (AR) is a potential target in metastatic breast cancer (MBC), and 16?-[18F]-fluoro-5?-dihydrotestosterone positron emission tomography ([18F]-FDHT-PET) can be used for noninvasive visualisation of AR. [18F]-FDHT uptake reduction during AR-targeting therapy reflects AR occupancy might predictive treatment response. We assessed the feasibility [18F]-FDHT-PET to det...

AIM Preoperative detection of extranodal spread (ENS) in head and neck cancer can have important consequences for patient management. The aim of this study was to determine whether 18-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) or a combination with Magnetic Resonance Imaging (MRI) could more accurately predict ENS, especially with the near availability of fully integrated [1...

[18f]kf, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18o]h2o>95%) with high energy protons in nrcam cyclotron. after the extraction of fluoride from enriched water as kf, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable for...

The discovery of the Warburg effect in the early twentieth century followed by the development of the fluorinated glucose analogue 18F-fluorodeoxyglucose (18F-FDG) and the invention of positron emission tomographs laid the foundation of clinical PET/CT. This review discusses the challenges and obstacles in clinical adoption of this technique. We then discuss advances in instrumentation, includi...

hemangioma of the rib is a rare benign vascular tumor. herein, we report a 63-year-old man presenting with hemangioma of the left sixth rib. an osteolytic eccentric expansive mass with calcification and focal cortical disruption was detected on chest computed tomography (ct). the mass showed low 2-deoxy-2-[18f]-fluoro-d-glucose (18f-fdg) avidity on positron emission tomography. the patient unde...

[18F]Fluorodeoxyglucose ([18F]FDG) is a positron emission radiotracer whose biodistribution is similar to glucose. The similar biodistribution of [18F]FDG and glucose in the human body requires a fasting condition for at least six hours prior to performing a [18F]FDG positron emission tomography ([18F]FDG PET) study.In human studies, FDG PET images, in either the fasting state or the glucose-lo...

BACKGROUND 3'-Deoxy-3'-[18F]-fluorothymidine ([18F]FLT) is being investigated as a Positron Emission Tomography (PET) proliferation biomarker. The mechanism of cellular [18F]FLT retention has been assigned primarily to alteration of the strict transcriptionally regulated S-phase expression of thymidine kinase 1 (TK1). This, however, does not explain how anticancer agents acting primarily throug...

In the situation of biochemical recurrence (BCR) prostate cancer (PCa) it is important to distinguish between local in bed and systemic disease progression. Conventional imaging modalities have a limited role, especially patients with low specific antigen (PSA) levels. recent years, role positron emission tomography combined computed (PET/CT) PSMA-labeled ligands has grown, but there currently ...

This study aimed to evaluate the prognostic value of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) uptake determined by positron emission tomography (PET) in patients with non-small cell lung cancer (NSCLC) in relation to disease stage and/or tumor histology. A retrospective review of 144 patients with newly diagnosed lung cancer undergoing PET imaging was performed. Differences in survival were co...