OBJECTIVES To evaluate the comparative efficacy and tolerability of topical calcipotriol in the treatment of mild to moderate chronic plaque psoriasis. DESIGN Quantitative systematic review of randomised controlled trials. SUBJECTS 6038 patients with plaque psoriasis reported in 37 trials. MAIN OUTCOME MEASURES Mean difference in percentage change in scores on psoriasis area and severity ...

In numerous studies charge remote fragmentation (CRF) has been shown to be a powerful technique for determination of primary structure by allowing location of double bonds, various functional groups, and branching in a variety of compound types directly by mass spectrometry. Instrumentation and ionization methods traditionally used for CRF, however, are becoming rare, in large part because ESI ...

E ugene M. Farber, MD, for 36 years professor and chairman of the Department of Dermatology, Stanford University School of Medicine, Stanford, Calif, and president of the Psoriasis Research Institute of Palo Alto, Calif, died November 10, 2000, after a brief illness. Farber was 83 years old. He was a native of Buffalo, NY, receiving his bachelor of arts degree from Oberlin College, Oberlin, Ohi...

Psoriasis is a chronic condition which causes the inflammation of the skin due to the activation of immune system leading to abnormal keratinocytes proliferation. The keratinocytes mature within a week as compared to normal cycle of 27 to 28 days. The oldest of the treatment includes the use of coal tar, Dithranol, sunlight, Dead Sea salts and emollients. Dermatologists now have a host of new t...

Psoriasis is a common, chronic, relapsing, papulo-squamous dermatitis, with overlying silvery scales. Psoriasis is an autoimmune disease. Genetic and environmental factors play a important role in psoriasis. The most commonly affected sites are the scalp, elbows, knees, umbilicus, genitalia, sacrum and shins. Psoriasis affects 3% of the population of the world. First-line treatments are topical...

Mild to moderate psoriasis is a disease that can often be treated with topical medications. The diversity of topical therapies and their disparate side effects complicates treatment planning. Our purpose is to compare the rates of adverse events associated with different topical psoriasis treatments. A review of medical literature from 1996 to March, 2002 was conducted using guidelines set by Q...

Between 50 % and 80 % of patients with psoriasis have involvement of the scalp. The clinical presentation of scalp psoriasis can be very varied, with disease severity ranging from mild to extremely severe.The disease may have a major psychological impact. Treatment should be tailored to each individual in order to achieve a good clinical response or blanching that lasts for as long as possible,...

porokeratosis with calcipotriol Editor, Disseminated superficial actinic porokeratosis (DSAP) is the most common type of porokeratosis. It is related to sun exposure and an autosomal dominant inheritance pattern is recognized. No ideal treatment of this clonal disorder of keratinization exists. We describe a patient in whom the complete resolution of lesions was achieved with topical treatment ...

Previous work has shown that the presence of a phorbol ester tumor promoter, phorbol 12-myristate 13-acetate (PMA), during a single-step selection for methotrexate (MTX)-resistant mouse 3T6 cells results in an up to 100-fold increase in the incidence of MTX-resistant, colony-forming cells. MTX resistance of most of these cells is due to amplification of the gene for dihydrofolate reductase (DHF...

A bullous eruption in a patient with psoriasis was first described by Bloom in 1929 (as cited by Weber) (1). Since then there have been several reports of bullous pemphigoid occurring during the treatment of psoriasis, especially after ultraviolet (UV) B exposure. Comorbidity of these two diseases without treatment has also been reported (2,3). Psoriasis is one of the most common chronic inflam...