Anthelmintic resistance is widespread in gastrointestinal nematode populations, such that there is a consistent need to search for new anthelmintics. However, the cost of screening for new compounds is high and has a very low success rate. Using the knowledge of traditional healers from Borneo Rainforests (Sarawak, Malaysia), we have previously shown that some traditional medicinal plants are a...

Drug development begins with medicinal plants as valuable materials. Euphorbia hirta (EH) andNauclea latifolia (NL) are important having applications in the management ofinfectious diseases. This research aimed at evaluating EH and NL leaves for their anthelminticproperty establishment of probable dauer diapause effect induced via interaction daf-12nuclear receptor worms using standard procedur...

Objective: This study was conducted to evaluate the anthelmintic activity of ethanolic leaf extract of Senna occidentalis on rat tapeworm Hymenolepis diminuta. Methods: Adult H. diminuta worms were obtained from laboratory maintained infection in rats. Different concentrations of crude ethanolic leaf extracts of S. occidentalis were tested in vitro on H. diminuta and praziquantel (PZQ) was used...

The habitat of endophytic bacteria in plant tissues making it automatically used by plants to protect themselves against pathogenic bacteria. Endophytic have been applied various fields, including agriculture, pharmacy, medicine, and biotechnology. This review was carried out summarize recent studies focusing on the diversity derived from traditional medicinal which antibacterial activity extra...

Infections with parasitic helminths are important causes of morbidity and mortality worldwide. New drugs that are parasite specific and minimally toxic to the host are needed to counter these infections effectively. Here we report the finding of a previously unidentified compound, nafuredin, from Aspergillus niger. Nafuredin inhibits NADH-fumarate reductase (complexes I + II) activity, a unique...

Although the molecular bases of resistance to anthelmintic families have been intensively studied, the contributing factors for the development of anthelmintic resistance are less well known. Clear recommendations must be given to farmers in order to delay the onset of anthelmintic resistance. Until now, the main advice has concerned the reduction of treatment frequency in order to slow down th...

The project work was designed to investigate the phytochemical and selected pharmacological activities (anti-diarrheal, analgesic, neuropharmacological behavior anthelmintic) of leaves Sanchezia nobilis. Hook. F. (Family: Acanthaceae). From its analysis we found presence reducing sugar, combined phenolic compounds, tannins, flavonoids, carbohydrates, gums, steroids, alkaloids, glycosides terpen...

The current research is the investigation of an ethnopharmacological impact i.e., anthelmintic action of fruits of three traditionally used trees, i.e. Pterospermum acerifolium Linn. Diospyros malabarica Kostel and Putranjiva roxburghii Wall. The crude extracts of fruits were obtained in polar and non-polar solvents i.e., petroleum ether, chloroform, methanol and water and evaluated for their i...

A series of N-benzylidenepyridin-2-amines (1a-j) were synthesized by heating 2-aminopyridine with different substituted aromatic aldehydes in the presence of toluene. The structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR, 13C NMR and mass spectral data. The compounds 1a-j were screened for anthelmintic activity. Test results revealed that the compounds showed par...

Schistosomiasis and trichuriasis are two of the most common neglected tropical diseases (NTD) that affect almost a billion people worldwide. There is only a limited number of effective drugs to combat these NTD. Medicinal plants are a viable source of parasiticides. In this study, we have investigated six of the 19 phytochemicals isolated from two Bhutanese medicinal plants, Corydalis crispa an...