tics are sudden, recurrent and stereotyped motor movements or vocalizations. dopamine blockers are the main pharmacological agents used in the management of tics. opioid antagonists have been reported to have been effective in the management of tics. in this article, two patients with chronic motor tic disorder are reported, whose symptoms were disappeared by using opioid substances.

losartan potassium, valsartan , telmisartan and irbesartan are angiotensin-ii-receptor antagonists (ara ii) group which used in treatment of hypertension alone or in combination with other drugs mainly hydrochlorothiazide. rp- hplc method was developed for the assay of three angiotensin-ii-receptor antagonists (ara-iis) in presence of hydrochlorothiazide. the method was performed by reversed ph...

background and aims: diabetic nephropathy (dn) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. the aim of this study was to investigate new modalities for treatment of diabetic nephropathy. methods:this study was a mini-review research to investigate drugs that are used for dn treatment. results...

Some 100 European cardiologists discussed calcium antagonists' role in the management of stable angina. Sixty-two percent of those involved used calcium antagonists rather than beta-blockers as first line therapy; 46% were prepared to use calcium antagonists in patients who had had a myocardial infarction more than 6 months previously. Only one tenth would use calcium antagonists in angina pati...

RATIONALE Given the large number of patients that does not respond sufficiently to currently available treatment for anxiety disorders, there is a need for improved treatment. OBJECTIVES We evaluated the anxiolytic effects of corticotropin releasing factor (CRF)1 receptor antagonists and glucocorticoid receptor (GR) antagonists in the separation-induced vocalization test in guinea pigs and tr...

Recently, we could show that gonadotropin-releasing hormone (GnRH)-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells in vitro and in vivo. In the present study, we have ascertained receptor binding and effects of GnRH-II antagonists on mitogenic signal transduction and on activation of proapoptotic protein Bax. The GnRH-II antagonists tested showed EC50 valu...

The G protein-coupled estrogen receptor (GPER, nomenclature as agreed by the NC-IUPHAR Subcommittee on [26]) was identified following observations of estrogen-evoked cyclic AMP signalling in breast cancer cells [2], which mirrored differential expression an orphan 7-transmembrane GPR30 [6]. There are both cell-surface and intracellular GPER [29, 34]. Selective agonist/ antagonists for have been...

Chemical communication is critical in establishing angiosperm–pollinator mutualisms. However, our understanding of how chemical shapes coevolution remains limited. Here, we integrated information theory to model three coevolutionary scenarios (I‒III), where the pollinator fitness always optimized by highest certainty provided plants, but plant determined (I) attracting pollinators, (II) uncerta...

We expanded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R) antagonists to determine their kinetic profiles and affinities. Many compounds showed high affinities and a diverse range of kinetic profiles. We found hA3R antagonists with very short residence time (RT) at the receptor (2.2 min for 5) and much longer RTs (e.g., 376 min for 27 or 391 min ...